IpiRecord: IPI00127012

IPI00127012 - Aph1a, ISOFORM 2 OF GAMMA-SECRETASE SUBUNIT APH-1A.
Uniprot Accession: Q6GTF1
Uniprot ID: Q6GTF1_MOUSE
Mapping: Chr 3, 95979401 - 95983693
Entrez Gene: 226548
Entrez MapView: Geneprod
MGI: MGI:2385110
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2499)
Rat: Aph1a, 29 KDA PROTEIN.
Mouse: Aph1a, ISOFORM 2 OF GAMMA-SECRETASE SUBUNIT APH-1A.
Mouse: Aph1a, ISOFORM 1 OF GAMMA-SECRETASE SUBUNIT APH-1A.
Rat: Aph1a, ANTERIOR PHARYNX DEFECTIVE 1A HOMOLOG.
Human: APH1A, ISOFORM 1 OF GAMMA-SECRETASE SUBUNIT APH-1A.
Human: APH1A, ANTERIOR PHARYNX DEFECTIVE 1 HOMOLOG A.
Human: APH1A, UNCHARACTERIZED PROTEIN APH1A.
Human: APH1A, ISOFORM 2 OF GAMMA-SECRETASE SUBUNIT APH-1A.

Annotations for Aph1a and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integral to membraneCIEA ISS IEA 
Golgi apparatusCIEA 
endoplasmic reticulumCIEA 
membraneCIEA 
protein bindingFIEA IEA IEA 
endopeptidase activityFIDA IMP ISS 
peptidase activityFISS 
positive regulation of enzyme activityPIEA IEA IEA 
metanephros developmentPIMP ISS 
protein processingPIEA ISS IEA 
Notch signaling pathwayPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (9)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
embryogenesis phenotypeMPUn Un
lethality-embryonic/perinatalMPUn Un
skeleton phenotypeMPUn
muscle phenotypeMPUn
nervous system phenotypeMPUn Un
normal phenotypeMPUn
cardiovascular system phenotypeMPUn Un
growth/size phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Alzheimer's disease (05010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Notch signaling pathway (04330)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway