| IPI00128152 - Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1. | |
|---|---|
| Uniprot Accession: P06795 | |
| Uniprot ID: MDR1_MOUSE | |
| Mapping: Chr 5, 8804192 - 8872314 | |
| Entrez Gene: 18669 | |
| Entrez MapView: |
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| MGI: MGI:97568 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4304) |
|---|
| Rat: Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1. |
| Mouse: Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1. |
| Rat: Abcb1b, ATP-BINDING CASSETTE PROTEIN B1B. |
| Rat: Abcb1b, 141 KDA PROTEIN. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| integral to membrane | C | RCA | IEA ISS ISS | |
| apical plasma membrane | C | IDA | ||
| intercellular canaliculus | C | IDA | ISS | |
| membrane fraction | C | ISS | ||
| membrane | C | IEA | IDA | |
| Golgi membrane | C | IDA | ||
| cell surface | C | ISS | ||
| xenobiotic-transporting ATPase activity | F | IEA | IEA | |
| transporter activity | F | IDA ISS | ||
| drug transporter activity | F | IMP | ||
| nucleoside-triphosphatase activity | F | IEA | ||
| ATPase activity | F | IEA | IEA | |
| ATPase activity, coupled to transmembrane movement of substances | F | IEA | IEA ISS | |
| ATP binding | F | IEA IEA | IEA ISS ISS | |
| protein binding | F | IPI | ||
| hydrolase activity | F | IEA | IEA | |
| nucleotide binding | F | IEA IEA | IEA | |
| establishment of blood-brain barrier | P | IMP | ||
| drug transport | P | IMP | ||
| response to ionizing radiation | P | IEP | ||
| transport | P | IEA IEA | IDA ISS | |
| response to steroid hormone stimulus | P | IEP | ||
| response to drug | P | ISS IMP | ||
| response to arsenic | P | IEP |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| homeostasis/metabolism phenotype | MP | Un | ||
| immune system phenotype | MP | Un | ||
| hematopoietic system phenotype | MP | Un | ||
| seizures | N | IED |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| HIV Infections | D | IED | ||
| Cholestasis | D | IEP | ||
| Kidney Failure, Chronic | D | IED | ||
| Liver Neoplasms, Experimental | D | IEP | ||
| Colorectal Neoplasms | D | IED | ||
| Diabetes Mellitus, Experimental | D | IED | ||
| Status Epilepticus | D | IEP | ||
| Brain Ischemia | D | IEP | ||
| Endotoxemia | D | IEP | ||
| Glioma | D | IED | ||
| Epilepsy, Temporal Lobe | D | IED |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| multidrug resistance protein mediated transport pathway | W | IDA |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| ABC transporters - General (02010) | Not present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |