IpiRecord: IPI00128861

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
integral to plasma membrane	C		TAS	ISS
plasma membrane	C	IEA	IDA	IEA ISS
secretory granule	C		TAS	ISS
extracellular space	C	IEA	IDA IDA IDA IDA IDA IDA IDA	IEA TAS ISS IDA
integral to membrane	C	IEA	IEA	IEA IDA
soluble fraction	C	TAS
membrane	C		IEA IEA
protein binding	F	IPI		IEA
tumor necrosis factor receptor binding	F	TAS	TAS TAS TAS TAS TAS TAS TAS IDA	IEA TAS ISS IDA
cytokine activity	F	IEA	IDA	IEA TAS ISS
apoptosis	P	TAS		IDA
response to virus	P	TAS
immune response	P		IEA
positive regulation of synaptic transmission	P			IMP
positive regulation of JNK cascade	P	IEA	IDA IGI	IEA ISS
regulation of osteoclast differentiation	P	IEA	IDA	IEA ISS
defense response to bacterium	P	IEA	IDA	IEA ISS
regulation of cell proliferation	P	IEA	IDA	ISS
positive regulation of cell proliferation	P		TAS	ISS
humoral immune response	P	IEA	IMP	IEA ISS
signal transduction	P	TAS TAS		IDA
positive regulation of neuron apoptosis	P			IMP
negative regulation of apoptosis	P			ISS
positive regulation of apoptosis	P			IMP
inflammatory response	P		TAS TAS	TAS ISS
transformed cell apoptosis	P		TAS TAS TAS	ISS
cell activation	P			IDA
leukocyte migration	P		IDA	ISS
negative regulation of glucose import	P	IEA	IDA	IEA ISS IDA
calcium-mediated signaling	P			IDA
positive regulation of inflammatory response	P			IMP
activation of NF-kappaB transcription factor	P	IDA	ISS	IEA
regulation of immunoglobulin secretion	P	IEA	IDA	IEA ISS
positive regulation of mitosis	P			IMP
positive regulation of interleukin-18 production	P			IMP
negative regulation of cell proliferation	P			IDA
defense response	P		IMP IMP	ISS
organ morphogenesis	P	IEA	IMP	IEA ISS
negative regulation of L-glutamate transport	P			IDA
positive regulation of transcription	P	IEA	IDA	IEA ISS
induction of apoptosis via death domain receptors	P	IEA	IGI	IEA ISS
glucose metabolic process	P	IEA	IDA	IEA ISS
protein import into nucleus, translocation	P	IDA		IEA
leukocyte adhesion	P	TAS
cell proliferation	P		TAS	ISS
anti-apoptosis	P	TAS
cellular extravasation	P	IEA	IDA	IEA ISS
osteoclast differentiation	P		IGI	ISS
positive regulation of transcription from RNA polymerase II promoter	P	IEA	IDA	IEA ISS
induction of apoptosis	P			IDA
regulation of protein amino acid phosphorylation	P	IEA	IDA	IEA ISS
negative regulation of transcription	P	IDA
JNK cascade	P	IEA	IGI
positive regulation of I-kappaB kinase/NF-kappaB cascade	P	IEA	IDA IDA IGI	IEA ISS IGI
response to mechanical stimulus	P			IEP
induction of apoptosis by extracellular signals	P		IDA	ISS
positive regulation of translational initiation by iron	P	IEA	IDA	IEA ISS
positive regulation of protein transport	P			IDA
multicellular organismal development	P	IEA	IMP	IEA ISS
regulation of transcription, DNA-dependent	P	TAS
negative regulation of transcription from RNA polymerase II promoter	P	IEA	IDA	IEA ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (26)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
skin/coat/nails phenotype	MP		Un Un
cellular phenotype	MP		Un Un
adipose tissue phenotype	MP		Un
behavior/neurological phenotype	MP		Un
homeostasis/metabolism phenotype	MP		Un Un
life span-post-weaning/aging	MP		Un Un Un Un
embryogenesis phenotype	MP		Un
lethality-embryonic/perinatal	MP		Un Un
immune system phenotype	MP		Un Un Un Un Un Un Un Un Un Un Un
liver/biliary system phenotype	MP		Un
growth/size phenotype	MP		Un Un Un
lethality-postnatal	MP		Un Un
skeleton phenotype	MP		Un Un
hematopoietic system phenotype	MP		Un Un Un Un Un Un Un Un Un
no phenotypic analysis	MP		Un
digestive/alimentary phenotype	MP		Un
cardiovascular system phenotype	MP		Un
muscle phenotype	MP		Un
dilated left ventricle	N			IED
decreased vasodilation	N			IED
decreased heart rate	N			IAGP
pancreas inflammation	N			IED
increased microalbumin excretion	N			IED
increased body weight	N			IAGP
increased blood pressure	N			IAGP
altered response to myocardial infarction	N			IED

Disease (19)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
??	D			ISS
Malaria	D			ISS
Coronary Restenosis	D			ISS
Neutropenia	D			ISS
Leukomalacia, Periventricular	D			IED
Alzheimer Disease	D			ISS
Mucocutaneous Lymph Node Syndrome	D			ISS
Pre-Eclampsia	D			ISS
Insulin Resistance	D			IED
Common Migraine	D			ISS
Intracranial Hemorrhages	D			ISS
Coronary Arteriosclerosis	D			ISS
Albuminuria	D			IED
Esophagitis, Peptic	D			IED
Heart Failure, Congestive	D			IED
Enterocolitis, Necrotizing	D			IED
Cerebral Infarction	D			ISS
Diabetic Nephropathies	D			IEDISS
Hypertension	D			IEDIAGPISS

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
c-Jun N-terminal kinases MAPK signaling pathway	W			IDA
Nuclear Factor Kappa B signaling pathway	W			IGI
p38 MAPK pathway	W			IDA

KEGG Pathway (12)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Prion disease (05060)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
T cell receptor signaling pathway (04660)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Alzheimer's disease (05010)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
Toll-like receptor signaling pathway (04620)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
TGF-beta signaling pathway (04350)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Adipocytokine signaling pathway (04920)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Fc epsilon RI signaling pathway (04664)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Apoptosis (04210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type II diabetes mellitus (04930)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Hematopoietic cell lineage (04640)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type I diabetes mellitus (04940)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cytokine-cytokine receptor interaction (04060)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway