IPI report for IPI00130589

IPI00130589 - Sod1, SUPEROXIDE DISMUTASE.
Uniprot Accession: P08228
Uniprot ID: SODC_MOUSE
Mapping: Chr 16, 90109717 - 90115188
Entrez Gene: 20655
Entrez MapView:
MGI: MGI:98351
+All IPI Database Cross References UniProtKB/Swiss-Prot: P08228 UniProtKB/Swiss-Prot: SODC_MOUSE ENSEMBL: ENSMUSP00000023707 ENSEMBL: ENSMUSG00000022982 REFSEQ_PROVISIONAL: NP_035564 REFSEQ_PROVISIONAL: GI:45597447 UniParc: UPI0000565717 MGI: MGI:98351 Entrez Gene: 20655 UniGene: Mm.276325 UniGene: Mm.431677 UniGene: Mm.439811 UniGene: Mm.458472 trome: MTR014414 trome: MTR065348 CleanEx: MM_SOD1 InterPro: IPR001424 Pfam: PF00080 PRINTS: PR00068 ProDom: PD000469 PROSITE: PS00087 PROSITE: PS00332 SUPERFAMILY: SSF49329 PANTHER: PTHR10003 GENE3D: G3DSA:2.60.40.200

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_10425)
Rat: Sod1, SUPEROXIDE DISMUTASE.
Mouse: Sod1, SUPEROXIDE DISMUTASE.
Mouse: Sod1, SUPEROXIDE DISMUTASE.
Rat: Sod1, 16 KDA PROTEIN.
Human: SOD1, SUPEROXIDE DISMUTASE.
Human: SOD1, SUPEROXIDE DISMUTASE.
Human: SOD1, 14 KDA PROTEIN.

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
cytoplasm	C	IDA IDA IDA IDA	TAS ISS	ISS ISS IDA
dendrite cytoplasm	C	IDA
mitochondrion	C	IDA	IDA	ISS IDA
protein complex	C	IDA
cell soma	C	IDA		IDA
plasma membrane	C	IDA IDA
cytosol	C	IDA
cytoplasmic vesicle	C	IDA
peroxisome	C	NAS
mitochondrial matrix	C	NAS
extracellular space	C	IDA IDA	IDA
nucleus	C	IDA IDA		IDA
extracellular matrix	C	IDA
protein phosphatase 2B binding	F	IDA
metal ion binding	F	IEA	IEA IEA	IEA
oxidoreductase activity	F	IEA	IEA	IEA
zinc ion binding	F	IDA	IEA	IEA
antioxidant activity	F	IEA	IEA	IEA
copper, zinc superoxide dismutase activity	F	IEA IDA IDA	IMP IMP IMP IMP IMP IMP IMP TAS TAS IDA IMP IMP	IDA ISS ISS IEA IDA IDA
protein homodimerization activity	F	NAS NAS
protein binding	F		IPI	TAS IMP
chaperone binding	F	IPI		IMP
superoxide dismutase activity	F		IDA IDA IMP IDA	ISS
copper ion binding	F	IDA	IEA	TAS IEA IMP
hydrogen peroxide biosynthetic process	P	IDA ISS	IMP	IMP IDA IDA
regulation of body size	P	ISS	IMP
cell aging	P	IEP IMP
thymus development	P	NAS
anti-apoptosis	P			IMP
response to reactive oxygen species	P		IMP
muscle maintenance	P	ISS	IMP
negative regulation of neuron apoptosis	P	ISS	IMP
response to oxidative stress	P	IEP IEP	IMP IMP IDA	TAS ISS ISS
response to ethanol	P	ISS	IMP
transmission of nerve impulse	P	ISS	IMP
retinal homeostasis	P	ISS	IMP
blood pressure regulation	P	ISS	IMP
ovarian follicle development	P	ISS	IMP
response to heat	P	ISS	IMP
cellular iron ion homeostasis	P	ISS	IMP
spermatogenesis	P	ISS	IMP
DNA fragmentation during apoptosis	P	ISS	IDA	ISS
response to copper ion	P			IMP
regulation of T cell differentiation in the thymus	P	NAS
negative regulation of cholesterol biosynthetic process	P	IDA
response to axon injury	P	ISS	IMP
myeloid cell homeostasis	P	ISS	IGI IMP
myelin maintenance in the peripheral nervous system	P	ISS	IMP
aging	P		IMP
locomotory behavior	P	ISS	IMP
placenta development	P	NAS
regulation of organ size	P	NAS
response to hydrogen peroxide	P	ISS	IMP
embryo implantation	P	ISS NAS	IMP
auditory receptor cell stereocilium organization and biogenesis	P	ISS	IMP IMP
relaxation of vascular smooth muscle	P	ISS	IMP IMP
negative regulation of apoptosis	P		IMP
response to nutrient levels	P			IDA
glutathione metabolic process	P	ISS	IMP
neurofilament cytoskeleton organization and biogenesis	P	ISS	IMP IGI
heart contraction	P	IDA	IMP
sensory perception of sound	P	ISS	IMP IMP IMP
positive regulation of cytokine production	P	IDA
positive regulation of enzyme activity	P	IDA
double-strand break repair	P	ISS	IMP
nervous system development	P			ISS
regulation of protein kinase activity	P	IDA
activation of MAPK activity	P	ISS	IDA	ISS
removal of superoxide radicals	P	ISS	IMP IMP IMP IMP IMP IGI IMP IMP TAS IMP IMP	TAS ISS IDA IDA
positive regulation of apoptosis	P	IC
response to superoxide	P	IDA	IMP IMP IMP
regulation of mitochondrial membrane potential	P	IMP
superoxide release	P		IDA	ISS
response to drug	P	ISS	IMP
superoxide metabolic process	P	IEA	IMP	TAS IDA IDA

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Mouse
cellular phenotype	MP	#
homeostasis/metabolism phenotype	MP	#
nervous system phenotype	MP	##
reproductive system phenotype	MP	#
hearing/vestibular/ear phenotype	MP	##
life span-post-weaning/aging	MP	#

Disease (16)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Rat
Heart Arrest	D	ISS
Brain Injuries	D	ISS
Diabetic Angiopathies	D	ISS
Nasal Polyps	D	ISS
Amyotrophic Lateral Sclerosis	D	ISS
Myocardial Infarction	D	ISS
Myocardial Diseases	D	ISS
Diabetes Mellitus, Experimental	D	ISS
Cataract	D	ISS
Behcet's Syndrome	D	ISS
Keratoconus	D	ISS
Macular Degeneration	D	ISS
Coronary Arteriosclerosis	D	ISS
Reperfusion Injury	D	ISS
Hepatorenal Syndrome	D	ISS
Hypertension	D	IED ISS ISS

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
amyotrophic lateral sclerosis disease pathway	W			ISSIEA ISS
hypertension	W			IDA

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Amyotrophic lateral sclerosis (ALS) (05030)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Neurodegenerative Disorders (01510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway

IpiRecord: IPI00130589

Annotations for Sod1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

Cellular Component

Biological Process

Molecular Function

Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

Disease (16)

Compiled Disease Ontology Annotations (from IPI)

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)