IpiRecord: IPI00131533

IPI00131533 - Casp8, CASPASE-8 PRECURSOR.
Uniprot Accession: Q4FK85
Uniprot ID: Q4FK85_MOUSE
Mapping: Chr 1, 58739978 - 58791553
Entrez Gene: 12370
Entrez MapView: Geneprod
MGI: MGI:1261423
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8758)
Rat: Casp8, CASPASE-8.
Mouse: Casp8, CASPASE-8 PRECURSOR.
Rat: Casp8, 55 KDA PROTEIN.
Human: CASP8, ISOFORM 1 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 7 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 2 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 3 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 5 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 6 OF CASPASE-8 PRECURSOR.
Human: CASP8, CASP8 PROTEIN.
Human: CASP8, ISOFORM 9 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 4 OF CASPASE-8 PRECURSOR.
Human: CASP8, ISOFORM 8 OF CASPASE-8 PRECURSOR.
Human: CASP8, CASPASE 8 ISOFORM I (FRAGMENT).

Annotations for Casp8 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIDA ISS 
Noc1p-Noc2p complexCIMP ISS 
mitochondrionCISS 
cytoskeletonCISS 
nucleusCIDA ISS 
protein bindingFIEA IPI IEA 
hydrolase activityFIEA 
signal transducer activityFISS 
cysteine-type peptidase activityFIEA ISS IEA 
peptidase activityFIMP ISS 
identical protein bindingFISS 
caspase activityFIEA IDA IDA IDA IDA ISS ISS IEA 
apoptosisPIDA IMP IDA IMP ISS 
neural tube formationPIMP ISS 
regulation of apoptosisPIEA IEA IEA 
heart developmentPIMP ISS 
angiogenesisPIMP ISS 
positive regulation of I-kappaB kinase/NF-kappaB cascadePISS 
apoptotic programPISS ISS 
macrophage differentiationPIMP ISS 
proteolysisPIEA IEA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (14)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn Un
immune system phenotypeMPUn Un Un Un
embryogenesis phenotypeMPUn Un Un
lethality-embryonic/perinatalMPUn Un Un
muscle phenotypeMPUn Un Un
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn Un Un
respiratory system phenotypeMPUn
cardiovascular system phenotypeMPUn Un Un
hematopoietic system phenotypeMPUn Un Un Un Un
life span-post-weaning/agingMPUn
liver/biliary system phenotypeMPUn
growth/size phenotypeMPUn Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
programmed cell death pathwayWIEA
mitogen activated protein kinase signaling pathwayWIEA
Huntington disease pathwayWIEA

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Huntington's disease (05040)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Dentatorubropallidoluysian atrophy (DRPLA) (05050)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Neurodegenerative Disorders (01510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway