IpiRecord: IPI00132238

IPI00132238 - Pdgfb, PLATELET-DERIVED GROWTH FACTOR B CHAIN PRECURSOR.
Uniprot Accession: Q8R3X9
Uniprot ID: Q8R3X9_MOUSE
Mapping: Chr 15, 79823129 - 79842063
Entrez Gene: 18591
Entrez MapView: Geneprod
MGI: MGI:97528
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7331)
Rat: Pdgfb, SIMILAR TO PLATELET-DERIVED GROWTH FACTOR B CHAIN PRECURSOR.
Mouse: Pdgfb, PLATELET-DERIVED GROWTH FACTOR B CHAIN PRECURSOR.
Mouse: Pdgfb, PLATELET DERIVED GROWTH FACTOR, B POLYPEPTIDE.
Rat: Pdgfb, PDGF PROTEIN (FRAGMENT).
Human: PDGFB, PLATELET-DERIVED GROWTH FACTOR B CHAIN PRECURSOR.
Human: PDGFB, PLATELET-DERIVED GROWTH FACTOR BETA ISOFORM 2, PREPROPROTEIN.

Annotations for Pdgfb and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
extracellular spaceCRCA ISS 
extracellular regionCNAS ISS 
membraneCIEA IEA IEA 
cytoplasmCIDA 
growth factor activityFIEA IEA IEA IEA 
platelet-derived growth factor receptor bindingFNAS IMP ISS 
regulation of peptidyl-tyrosine phosphorylationPIDA ISS 
transforming growth factor beta receptor signaling pathwayPIMP 
response to hypoxiaPIEP 
regulation of progression through cell cyclePIEA IEA IEA IEA 
DNA replicationPIEP 
negative regulation of cell migrationPIGI 
cell proliferationPIEA IEA 
actin cytoskeleton organization and biogenesisPIDA ISS 
response to woundingPNAS ISS 
cellular processPIEA 
cell projection biogenesisPIDA ISS 
positive regulation of endothelial cell proliferationPIGI 
substrate-bound cell migrationPIDA ISS 
regulation of cell proliferationPIEP 
cell growthPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMP#
homeostasis/metabolism phenotypeMP###
immune system phenotypeMP##
embryogenesis phenotypeMP##
lethality-embryonic/perinatalMP##
muscle phenotypeMP###
renal/urinary system phenotypeMP###
nervous system phenotypeMP###
respiratory system phenotypeMP#
vision/eye phenotypeMP###
cardiovascular system phenotypeMP###
reproductive system phenotypeMP#
hematopoietic system phenotypeMP##
no phenotypic analysisMP#
growth/size phenotypeMP#
pigmentation phenotypeMP#
liver/biliary system phenotypeMP#

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Hypertension, PulmonaryDIEP

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
transforming growth factor-beta signaling pathwayWIMP

KEGG Pathway (6)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Gap junction (04540)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway