IpiRecord: IPI00134311

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
extracellular region	C	IC IEA	IEA	IEA
secretory granule	C		IDA	IDA IEA
extracellular space	C		RCA	ISS
cellular_component	C			ND
small nucleolar ribonucleoprotein complex	C		IDA	ISS IEA
nucleus	C		IDA	ISS IEA
soluble fraction	C			IDA
protein binding	F	IPI
molecular_function	F			ND
insulin-like growth factor binding	F	IPI
insulin receptor binding	F	IDA
hormone activity	F	NAS IEA	TAS	ISS IEA
protease binding	F			IPI
alpha-beta T cell activation	P	IDA
positive regulation of vasodilation	P	NAS
cell death	P	NAS
lipid catabolic process	P		IDA	ISS IEA
ER overload response	P		IMP	ISS IEA
regulation of apoptosis	P		IMP	ISS IEA
carbohydrate metabolic process	P	IEA	IEA	IEA
cell surface receptor linked signal transduction	P	TAS
activation of MAPK activity	P		IDA	ISS IEA
generation of precursor metabolites and energy	P	TAS
regulation of phosphorylation	P		IDA	ISS IEA
glucose metabolic process	P	TAS	IMP	ISS IEA
positive regulation of nitric-oxide synthase activity	P	NAS
cell-cell signaling	P	IC
negative regulation of protein catabolic process	P	IDA
activation of JNK activity	P		IDA
positive regulation of cytokine secretion	P	IDA
regulation of protein secretion	P	IDA
negative regulation of vasodilation	P	NAS
positive regulation of nitric oxide biosynthetic process	P	NAS
acute-phase response	P	NAS
glucose transport	P	IDA IDA	TAS	ISS
regulation of glucose-6-phosphatase activity	P		IDA
insulin receptor signaling pathway	P		IDA	ISS IEA
biological_process	P			ND

Cellular Component

Biological Process

Molecular Function

Phenotype (20)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
skin/coat/nails phenotype	MP		Un
cellular phenotype	MP		Un Un
adipose tissue phenotype	MP		Un
behavior/neurological phenotype	MP		Un
endocrine/exocrine gland phenotype	MP		Un Un Un Un
homeostasis/metabolism phenotype	MP		Un Un Un Un
embryogenesis phenotype	MP		Un
immune system phenotype	MP		Un Un Un
skeleton phenotype	MP		Un
lethality-postnatal	MP		Un Un Un
renal/urinary system phenotype	MP		Un Un Un Un
nervous system phenotype	MP		Un
vision/eye phenotype	MP		Un
cardiovascular system phenotype	MP		Un
digestive/alimentary phenotype	MP		Un Un Un Un
hematopoietic system phenotype	MP		Un
reproductive system phenotype	MP		Un
liver/biliary system phenotype	MP		Un Un
growth/size phenotype	MP		Un Un Un Un
life span-post-weaning/aging	MP		Un Un

Disease (3)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Obesity	D			ISS
Diabetes Mellitus, Non-Insulin-Dependent	D			ISS
Hyperinsulinism	D			ISS

Pathway (4)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
Parkinson disease pathway	W			IEA
dentatorubral-pallidoluysian atrophy disease pathway	W			IEA
insulin signaling pathway	W			ISS
Alzheimer disease pathway	W			IEA

KEGG Pathway (8)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Regulation of autophagy (04140)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
mTOR signaling pathway (04150)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type II diabetes mellitus (04930)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type I diabetes mellitus (04940)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Dentatorubropallidoluysian atrophy (DRPLA) (05050)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Insulin signaling pathway (04910)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Maturity onset diabetes of the young (04950)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway