IpiRecord: IPI00135366

IPI00135366 - Apaf1, ISOFORM 1 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Uniprot Accession: O88879-1
Uniprot ID: APAF_MOUSE
Mapping: Chr 10, 90419117 - 90512538
Entrez Gene: 11783
Entrez MapView: Geneprod
MGI: MGI:1306796
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_6910)
Rat: Apaf1, APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Mouse: Apaf1, ISOFORM 1 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Mouse: Apaf1, APAF1 PROTEIN.
Mouse: Apaf1, ISOFORM 2 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 1 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 2 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 3 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 4 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 5 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, ISOFORM 6 OF APOPTOTIC PROTEASE-ACTIVATING FACTOR 1.
Human: APAF1, 10 KDA PROTEIN.
Human: APAF1, 3 KDA PROTEIN.

Annotations for Apaf1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA 
cytosolCTAS IDA ISS ISS 
membraneCIEA 
soluble fractionCIDA IEA ISS 
nucleusCIDA IEA ISS 
intracellularCIEA IEA 
caspase activator activityFISS 
protein bindingFIEA ISS 
ATP bindingFIEA IEA IEA 
apoptotic protease activator activityFIPI IEA ISS 
dipeptidyl-peptidase IV activityFIEA 
peptidase activityFIEA 
identical protein bindingFIPI IEA ISS 
nucleotide bindingFIEA IEA ISS 
caspase activation via cytochrome cPISS 
defense responsePIEA IEA 
forebrain developmentPIMP IEA ISS ISS 
induction of apoptosisPIDA 
nervous system developmentPISS 
regulation of apoptosisPIEA IEA ISS 
proteolysisPIEA 
caspase activationPTAS ISS 
neural tube closurePIMP IMP IEA ISS ISS 
brain developmentPIMP ISS ISS 
multicellular organismal developmentPIMP IEA ISS 
apoptosisPIEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (18)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un Un
craniofacial phenotypeMPUn Un Un
behavior/neurological phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
immune system phenotypeMPUn
lethality-embryonic/perinatalMPUn Un Un
lethality-postnatalMPUn
skeleton phenotypeMPUn Un Un
nervous system phenotypeMPUn Un Un
hearing/vestibular/ear phenotypeMPUn Un
tumorigenesisMPUn
vision/eye phenotypeMPUn Un
digestive/alimentary phenotypeMPUn Un
limbs/digits/tail phenotypeMPUn Un
life span-post-weaning/agingMPUn
reproductive system phenotypeMPUn
respiratory system phenotypeMPUn
abnormal apoptosisNISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway