IPI report for IPI00170221

IpiRecord: IPI00170221

IPI00170221 - Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.
Uniprot Accession: A2AFI0
Uniprot ID: A2AFI0_MOUSE
Mapping: Chr X, 53578271 - 53685513
Entrez Gene: 73341
Entrez MapView:
MGI: MGI:1920591
+All IPI Database Cross References UniProtKB/Swiss-Prot: Q8K4I3 UniProtKB/Swiss-Prot: ARHG6_MOUSE Vega: OTTMUSP00000019411 UniProtKB/TrEMBL: A2AFI0 UniProtKB/TrEMBL: A2AFI0_MOUSE ENSEMBL: ENSMUSP00000033468 ENSEMBL: ENSMUSG00000031133 REFSEQ_PROVISIONAL: NP_690014 REFSEQ_PROVISIONAL: GI:22779885 UniParc: UPI0000DBEDF3 MGI: MGI:1920591 Entrez Gene: 73341 UniGene: Mm.261443 trome: MTR001763 RZPD: Mm.261443 CleanEx: MM_ARHGEF6 InterPro: IPR001715 InterPro: IPR001849 InterPro: IPR000219 InterPro: IPR001452 Pfam: PF00307 Pfam: PF00169 Pfam: PF00621 Pfam: PF00018 ProDom: PD000066 SMART: SM00033 SMART: SM00233 SMART: SM00325 SMART: SM00326 PROSITE: PS50021 PROSITE: PS50010 PROSITE: PS50003 PROSITE: PS50002 SUPERFAMILY: SSF50044 GENE3D: G3DSA:1.20.900.10

IPI00170221 - Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.

Uniprot Accession: A2AFI0

Uniprot ID: A2AFI0_MOUSE

Mapping: Chr X, 53578271 - 53685513

Entrez Gene: 73341

Entrez MapView: Geneprod

MGI: MGI:1920591

+All IPI Database Cross References

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15062)
Rat: arhgef6, RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.
Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.
Human: ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Human: ARHGEF6, ISOFORM 2 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.
Human: ARHGEF6, UNCHARACTERIZED PROTEIN ARHGEF6.

IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15062)

Rat: arhgef6, RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Mouse: Arhgef6, RAC/CDC42 GUANINE NUCLEOTIDE EXCHANGE FACTOR (GEF) 6.

Human: ARHGEF6, ISOFORM 1 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Human: ARHGEF6, ISOFORM 2 OF RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 6.

Human: ARHGEF6, UNCHARACTERIZED PROTEIN ARHGEF6.

Annotations for Arhgef6 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
cellular_component	C		ND	ND
intracellular	C	IEA	IEA	ISS IEA
guanyl-nucleotide exchange factor activity	F		IEA IEA	IEA
GTPase activator activity	F			ISS
molecular_function	F		ND	ND
Rho guanyl-nucleotide exchange factor activity	F	IEA	IEA	ISS IEA
apoptosis	P			ISS
intracellular signaling cascade	P		IEA
regulation of Rho protein signal transduction	P	IEA	IEA	IEA
JNK cascade	P			ISS
biological_process	P		ND	ND

Cellular Component

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key:

Rat

Mouse

Human

Rat & Mouse

Mouse & Human

Rat & Human

Rat, Mouse & Human

SVG image

Phenotype (0)

There are no Mammalian Phenotype Ontology annotations for this protein in the database

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Mental Retardation	D			ISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway