IpiRecord: IPI00229894

IPI00229894 - Apc, ISOFORM 4 OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Uniprot Accession: Q61315-4
Uniprot ID: APC_MOUSE
Mapping: Chr 18, 34345794 - 34443382
Entrez Gene: 11789
Entrez MapView: Geneprod
MGI: MGI:88039
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_13448)
Rat: Apc, ADENOMATOUS POLYPOSIS COLI PROTEIN.
Mouse: Apc, ISOFORM 1 OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Mouse: Apc, ISOFORM 3 OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Mouse: Apc, ISOFORM 4 OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Mouse: Apc, SEQUENCE.
Mouse: Apc, ISOFORM 2 OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Rat: Apc, 307 KDA PROTEIN.
Human: APC, ISOFORM LONG OF ADENOMATOUS POLYPOSIS COLI PROTEIN.
Human: APC, ISOFORM SHORT OF ADENOMATOUS POLYPOSIS COLI PROTEIN.

Annotations for Apc and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
microtubuleCIDA 
nucleusCIDA ISS ISS ISS IDA ISS 
lateral plasma membraneCISS ISS 
cytoplasmCIDA ISS IDA ISS 
beta-catenin destruction complexCISS 
kinetochoreCISS 
neuron projectionCIDA 
centrosomeCISS 
growth coneCIDA 
microtubule bindingFIEA IDA ISS 
bindingFIEA 
peroxidase activityFRCA ISS 
protein kinase bindingFISS 
protein kinase CK2 regulator activityFISS 
beta-catenin bindingFIDA IPI ISS ISS ISS 
protein bindingFIPI ISS 
axis specificationPIMP ISS 
establishment and/or maintenance of cell polarityPIDA 
Wnt receptor signaling pathwayPIDA IMP ISS IEA 
negative regulation of cyclin-dependent protein kinase activityPISS 
cell cycle arrestPISS 
negative regulation of progression through cell cyclePIEA 
neurite developmentPIMP 
negative regulation of cell proliferationPISS 
cell adhesionPISS 
cell cyclePIEA IEA 
protein complex assemblyPISS ISS 
regulation of progression through cell cyclePIEA 
negative regulation of microtubule depolymerizationPISS 
anterior/posterior pattern formationPIMP ISS 
response to drugPIEP 
dorsal/ventral pattern formationPIMP ISS 
response to DNA damage stimulusPISS 
signal transductionPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (24)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
skin/coat/nails phenotypeMPUn Un Un
cellular phenotypeMPUn Un Un Un
behavior/neurological phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn Un Un
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
immune system phenotypeMPUn Un
lethality-embryonic/perinatalMPUn Un Un Un Un Un
lethality-postnatalMPUn Un
skeleton phenotypeMPUn Un
nervous system phenotypeMPUn
touch/vibrissae phenotypeMPUn
vision/eye phenotypeMPUn
tumorigenesisMPUn Un Un Un Un Un Un Un Un Un Un
normal phenotypeMPUn
cardiovascular system phenotypeMPUn Un Un Un Un
digestive/alimentary phenotypeMPUn Un Un Un Un Un Un Un
hearing/vestibular/ear phenotypeMPUn
hematopoietic system phenotypeMPUn Un Un Un Un
pigmentation phenotypeMPUn
liver/biliary system phenotypeMPUn
growth/size phenotypeMPUn Un Un
life span-post-weaning/agingMPUn Un Un Un Un Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway