IpiRecord: IPI00307991

IPI00307991 - Crk, ISOFORM CRK-II OF PROTO-ONCOGENE C-CRK.
Uniprot Accession: Q91VM1
Uniprot ID: Q91VM1_MOUSE
Mapping: Chr 11, 75495505 - 75522289
Entrez Gene: 12928
Entrez MapView: Geneprod
MGI: MGI:88508
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_9537)
Rat: Crk, ISOFORM CRK-I OF PROTO-ONCOGENE C-CRK.
Mouse: Crk, ISOFORM CRK-II OF PROTO-ONCOGENE C-CRK.
Mouse: Crk, ISOFORM CRK-I OF PROTO-ONCOGENE C-CRK.
Mouse: Crk, CT-10 RELATED KINASE 3.
Mouse: Crk, SEQUENCE.
Mouse: Crk, V-CRK SARCOMA VIRUS CT10 ONCOGENE HOMOLOG.
Mouse: Crk, CRK PROTEIN.
Rat: Crk, ISOFORM CRK-II OF PROTO-ONCOGENE C-CRK.
Rat: Crk, 29 KDA PROTEIN.
Human: CRK, ISOFORM CRK-II OF PROTO-ONCOGENE C-CRK.
Human: CRK, V-CRK SARCOMA VIRUS CT10 ONCOGENE HOMOLOG ISOFORM B.
Human: CRK, ISOFORM CRK-I OF PROTO-ONCOGENE C-CRK.

Annotations for Crk and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleusCISS 
cytoplasmCIEA ISS 
intracellularCIEA 
membraneCIEA 
protein binding, bridgingFIMP 
protein bindingFIPI IPI IPI IPI ISS ISS 
kinase activityFIEA 
protein phosphorylated amino acid bindingFIDA ISS 
protein domain specific bindingFIPI 
SH2 domain bindingFISS 
SH3/SH2 adaptor activityFISS 
actin cytoskeleton organization and biogenesisPISS 
activation of JNK activityPTAS 
regulation of progression through cell cyclePIEA 
intracellular signaling cascadePIEA IEA 
cellular processPIEA 
regulation of cell motilityPTAS 
regulation of Rac protein signal transductionPIMP 
regulation of transcription from RNA polymerase II promoterPISS 
cell motilityPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
lethality-embryonic/perinatalMPUn
muscle phenotypeMPUn
respiratory system phenotypeMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
normal phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (5)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway