IpiRecord: IPI00314969

IPI00314969 - Brca2, BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN HOMOLOG.
Uniprot Accession: Q8VHD0
Uniprot ID: Q8VHD0_MOUSE
Mapping: Chr 5, 150791023 - 150838107
Entrez Gene: 12190
Entrez MapView: Geneprod
MGI: MGI:109337
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_10748)
Rat: Brca2, BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN HOMOLOG.
Mouse: Brca2, BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN HOMOLOG.
Human: BRCA2, BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN.

Annotations for Brca2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cellular_componentCND 
secretory granuleCIDA ISS 
nucleusCIDA IDA IDA IDA IDA ISS ISS IEA 
centrosomeCIDA 
BRCA2-MAGE-D1 complexCIDA 
cytoplasmCIEA IDA ISS IEA 
extracellular spaceCISS 
histone acetyltransferase activityFIDA 
gamma-tubulin bindingFIPI 
transcription activator activityFIDA ISS IEA 
protein bindingFIPI IPI IPI IPI IPI IPI IPI IPI IPI ISS ISS IPI ISS ISS IEA 
single-stranded DNA bindingFIDA ISS 
male meiosis IPIMP 
mitotic cell cycle checkpointPISS 
mammary gland developmentPIMP 
nucleotide-excision repairPIMP 
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorPIMP 
response to gamma radiationPIMP IMP 
regulation of transcriptionPISS 
multicellular organism growthPIMP 
chromatin remodelingPISS 
double-strand break repair via homologous recombinationPIMP ISS ISS 
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosisPIMP IGI 
response to genisteinPIDA 
replication fork protectionPIMP 
DNA recombinationPIDA 
DNA repairPIEA IEA IEA 
negative regulation of mammary gland epithelial cell proliferationPIDA 
DNA damage response, signal transduction resulting in induction of apoptosisPIGI 
regulation of progression through cell cyclePISS 
double-strand break repairPIMP IMP IMP 
response to nutrientPIEP 
cytokinesis during cell cyclePIDA IMP 
cell proliferationPIMP IMP IMP IMP 
chromosome organization and biogenesis (sensu Eukaryota)PIMP 
response to estrogen stimulusPIDA IEP 
response to UV-CPIMP 
cell agingPIMP 
response to X-rayPIMP IMP 
positive regulation of progression through mitotic cell cyclePIMP 
spermatogenesisPIMP IMP 
chordate embryonic developmentPIMP 
female gonad developmentPIMP 
establishment and/or maintenance of chromatin architecturePISS 
brain developmentPIMP 
oocyte maturationPIMP 
inner cell mass cell proliferationPIMP 
regulation of transcription, DNA-dependentPIC 
regulation of S phase of mitotic cell cyclePNAS ISS 
response to DNA damage stimulusPIMP IMP ISS 
centrosome duplicationPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
skin/coat/nails phenotypeMPUn
life span-post-weaning/agingMPUn Un Un
growth/size phenotypeMPUn Un
immune system phenotypeMPUn
embryogenesis phenotypeMPUn Un Un
lethality-embryonic/perinatalMPUn Un Un Un Un Un Un
reproductive system phenotypeMPUn
normal phenotypeMPUn Un Un Un Un Un
nervous system phenotypeMPUn
tumorigenesisMPUn Un Un Un Un Un
limbs/digits/tail phenotypeMPUn
lethality-postnatalMPUn
abnormal mammary gland developmentNIAGP
abnormal spermatogenesisNIAGP
cataractsNIAGP
osteosarcomaNIAGP

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Fanconi AnemiaDISS
Breast NeoplasmsDISS
OsteosarcomaDIAGP
CataractDIAGP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway