IpiRecord: IPI00323590

IPI00323590 - Cbl, E3 UBIQUITIN-PROTEIN LIGASE CBL.
Uniprot Accession: P22682
Uniprot ID: CBL_MOUSE
Mapping: Chr 9, 43900257 - 43985041
Entrez Gene: 12402
Entrez MapView: Geneprod
MGI: MGI:88279
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7919)
Rat: RGD1561386_predicted, SIMILAR TO CASITAS B-LINEAGE LYMPHOMA.
Mouse: Cbl, E3 UBIQUITIN-PROTEIN LIGASE CBL.
Mouse: Cbl, CASITAS B-LINEAGE LYMPHOMA.
Human: CBL, E3 UBIQUITIN-PROTEIN LIGASE CBL.
Human: CBL, CDNA FLJ34981 FIS, CLONE OCBBF2000982.

Annotations for Cbl and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA IEA 
nucleusCIEA IEA IEA 
plasma membraneCIDA 
metal ion bindingFIEA 
ubiquitin-protein ligase activityFTAS 
protein bindingFIPI IPI IEA 
calcium ion bindingFIEA IEA IEA IEA 
signal transducer activityFIEA IEA IEA 
zinc ion bindingFIEA IEA IEA IEA 
transcription factor activityFTAS 
ligase activityFIEA IEA 
positive regulation of receptor mediated endocytosisPTAS 
epidermal growth factor receptor signaling pathwayPTAS 
ubiquitin cyclePIEA 
cell surface receptor linked signal transductionPTAS IEA IEA 
protein ubiquitinationPTAS 
intracellular signaling cascadePIEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (22)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn Un Un
cellular phenotypeMPUn
craniofacial phenotypeMPUn Un
adipose tissue phenotypeMPUn Un
behavior/neurological phenotypeMPUn Un
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un Un
immune system phenotypeMPUn Un Un Un Un
lethality-embryonic/perinatalMPUn Un Un
lethality-postnatalMPUn
skeleton phenotypeMPUn
muscle phenotypeMPUn
respiratory system phenotypeMPUn
cardiovascular system phenotypeMPUn
limbs/digits/tail phenotypeMPUn Un
reproductive system phenotypeMPUn Un
hearing/vestibular/ear phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un Un Un Un
life span-post-weaning/agingMPUn
growth/size phenotypeMPUn Un Un Un
pigmentation phenotypeMPUn Un
liver/biliary system phenotypeMPUn Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Jak-STAT signaling pathway (04630)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway