IpiRecord: IPI00357545

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
kinetochore	C			ISS
integral to plasma membrane	C			ISS
endoplasmic reticulum	C		TAS	ISS IEA
integral to nuclear inner membrane	C			ISS
membrane fraction	C		IDA
integral to membrane	C	IEA	RCA	ISS IEA
membrane	C	IEA	IEA IEA	IEA
Golgi apparatus	C		IEA
mitochondrion	C		IEA	IEA
cell soma	C		IDA
cytosol	C		IDA
ATP binding	F		IEA	IEA
peptidase activity	F		IEA	IEA
hydrolase activity	F		IEA
protein binding	F		IPI	ISS ISS
transferase activity	F		IEA	IEA
kinase activity	F		IEA	IEA
nucleotide binding	F		IEA	IEA
protein maturation via proteolysis	P		IGI	ISS
anagen	P		IGI	ISS
membrane protein ectodomain proteolysis	P			ISS
response to hypoxia	P			IEP
apoptosis	P		IDA IDA
embryonic limb morphogenesis	P		IGI	ISS
protein folding	P		IEA	IEA
chromosome segregation	P			ISS
chromosome organization and biogenesis (sensu Eukaryota)	P			ISS
Notch receptor processing	P			ISS
amyloid precursor protein catabolic process	P			ISS
intracellular signaling cascade	P	IEA	IEA	IEA
positive regulation of enzyme activity	P			ISS
cell fate specification	P		IGI	ISS
positive regulation of apoptosis	P		IGI	ISS
protein processing	P			ISS
negative regulation of apoptosis	P		IDA IGI
Notch signaling pathway	P		IEA	IEA
apoptotic program	P			ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (22)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
cellular phenotype	MP		Un
craniofacial phenotype	MP		Un
skin/coat/nails phenotype	MP		Un Un
endocrine/exocrine gland phenotype	MP		Un
behavior/neurological phenotype	MP		Un
homeostasis/metabolism phenotype	MP		Un
immune system phenotype	MP		Un
embryogenesis phenotype	MP		Un Un
lethality-embryonic/perinatal	MP		Un Un
renal/urinary system phenotype	MP		Un
nervous system phenotype	MP		Un Un
hematopoietic system phenotype	MP		Un
respiratory system phenotype	MP		Un
vision/eye phenotype	MP		Un
digestive/alimentary phenotype	MP		Un
normal phenotype	MP		Un Un
cardiovascular system phenotype	MP		Un Un
limbs/digits/tail phenotype	MP		Un
life span-post-weaning/aging	MP		Un
growth/size phenotype	MP		Un Un Un
intracerebral hemorrhage	N			ISS
fibrosis	N			ISS

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
Alzheimer disease pathway	W			IEA ISS

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Alzheimer's disease (05010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Notch signaling pathway (04330)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Neurodegenerative Disorders (01510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway