IpiRecord: IPI00474424

IPI00474424 - Irak1, ISOFORM 2 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Uniprot Accession: A2AF18
Uniprot ID: A2AF18_MOUSE
Mapping: Chr X, 70266646 - 70276641
Entrez Gene: 16179
Entrez MapView: Geneprod
MGI: MGI:107420
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_15084)
Rat: Irak1_predicted, SIMILAR TO INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, ISOFORM 1 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, ISOFORM 2 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-1.
Mouse: Irak1, KINASE 1, FULL INSERT SEQUENCE.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-1A.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Mouse: Irak1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Rat: Irak1_predicted, 79 KDA PROTEIN.
Human: IRAK1, INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1 ISOFORM 3.
Human: IRAK1, ISOFORM 1 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Human: IRAK1, ISOFORM 3 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Human: IRAK1, ISOFORM 2 OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 1.
Human: IRAK1, PROTEIN.
Human: IRAK1, 25 KDA PROTEIN.
Human: IRAK1, 24 KDA PROTEIN.
Human: IRAK1, PROTEIN.

Annotations for Irak1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
soluble fractionCIDA 
membrane fractionCIDA 
ATP bindingFIEA IEA IEA IEA 
nucleotide bindingFIEA IEA 
protein bindingFIEA IPI IPI IPI IPI IDA IEA 
protein kinase activityFIEA IDA 
kinase activityFIDA 
protein serine/threonine kinase activityFIEA IEA IEA IEA IEA 
protein kinase bindingFISS 
interleukin-1 receptor bindingFIPI 
magnesium ion bindingFIEA 
receptor activityFIEA IEA 
transferase activityFIEA IEA 
innate immune responsePIEP 
protein amino acid phosphorylationPIEA IDA IDA IEA 
lipopolysaccharide-mediated signaling pathwayPIDA 
response to lipopolysaccharidePIDA 
cytokine and chemokine mediated signaling pathwayPIDA IMP 
signal transductionPIEA IDA IEA 
positive regulation of smooth muscle cell proliferationPIMP 
JNK cascadePIMP 
positive regulation of transcription from RNA polymerase II promoterPIMP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
immune system phenotypeMPUn Un
muscle phenotypeMPUn
cardiovascular system phenotypeMPUn
life span-post-weaning/agingMPUn

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
MyocarditisDIAGP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway