IpiRecord: IPI00474564

IPI00474564 - Abcc8, ATP-BINDING CASSETTE PROTEIN.
Uniprot Accession: Q9JL44
Uniprot ID: Q9JL44_MOUSE
Mapping: Chr 7, 45972565 - 46048075
Entrez Gene: 20927
Entrez MapView: Geneprod
MGI: MGI:1352629
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_571)
Rat: Abcc8, ISOFORM A OF ATP-BINDING CASSETTE TRANSPORTER SUB-FAMILY C MEMBER 8.
Mouse: Abcc8, ATP-BINDING CASSETTE PROTEIN.
Mouse: Abcc8, CLONE:D930031B21 PRODUCT:SULFONYLUREA RECEPTOR-1 HOMOLOG.
Mouse: Abcc8, ATP-BINDING CASSETTE, SUB-FAMILY C (CFTR/MRP), MEMBER 8.
Rat: Abcc8, 25 KDA PROTEIN.
Rat: Abcc8, 178 KDA PROTEIN.
Rat: Abcc8, 55 KDA PROTEIN.
Rat: Abcc8, ISOFORM B OF ATP-BINDING CASSETTE TRANSPORTER SUB-FAMILY C MEMBER 8.
Rat: Abcc8, ISOFORM C OF ATP-BINDING CASSETTE TRANSPORTER SUB-FAMILY C MEMBER 8.
Human: ABCC8, UNCHARACTERIZED PROTEIN ABCC8.
Human: ABCC8, ISOFORM 1 OF ATP-BINDING CASSETTE TRANSPORTER SUB-FAMILY C MEMBER 8.
Human: ABCC8, SULFONYLUREA RECEPTOR 1 VARIANT (FRAGMENT).
Human: ABCC8, 15 KDA PROTEIN.
Human: ABCC8, 19 KDA PROTEIN.
Human: ABCC8, 28 KDA PROTEIN.
Human: ABCC8, 18 KDA PROTEIN.
Human: ABCC8, 13 KDA PROTEIN.
Human: ABCC8, PROTEIN.
Human: ABCC8, 173 KDA PROTEIN.
Human: ABCC8, 10 KDA PROTEIN.
Human: ABCC8, 20 KDA PROTEIN.

Annotations for Abcc8 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integral to membraneCIEA IEA 
plasma membraneCIDA ISS 
ATP-sensitive potassium channel complexCIMP TAS 
membraneCIEA RCA IEA ISS 
sarcolemmaCIDA 
synaptic vesicle membraneCIMP 
ATP bindingFIEA IEA IEA IMP ISS 
syntaxin bindingFIPI 
receptor activityFIEA IEA IEA 
sulfonylurea receptor activityFIEA IEA TAS ISS 
potassium channel activityFIMP 
ATPase activity, coupled to transmembrane movement of substancesFIEA IEA 
ATPase activityFIEA IEA 
potassium ion transmembrane transporter activityFISS 
nucleotide bindingFIEA RCA IEA ISS 
potassium ion transportPIEA IEA ISS 
negative regulation of insulin secretionPIDA 
carbohydrate metabolic processPISS 
response to chemical stimulusPIDA 
transportPIEA IEA 
response to pHPIDA 
positive regulation of potassium ion transportPIDA 
response to zinc ionPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un
digestive/alimentary phenotypeMPUn
increased circulating insulin levelNIED

Disease (5)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Diabetes MellitusDISS
Diabetes Mellitus, Non-Insulin-DependentDISS
HyperinsulinismDISSISS
Cerebrovascular AccidentDIED
Parkinsonian DisordersDIEP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
ABC transporters - General (02010)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Type II diabetes mellitus (04930)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway