IpiRecord: IPI00474965

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
plasma membrane	C		RCA IDA	ISS ISS IDA
AP-2 adaptor complex	C			ISS
intracellular	C		IDA	ISS
nucleus	C			ISS
integral to plasma membrane	C		RCA	ISS
extracellular space	C			ISS
cytoskeleton	C		RCA	ISS
integral to membrane	C		RCA	ISS
membrane	C		IEA IEA
cytoplasm	C			ISS
endocytic vesicle	C		IDA	ISS IDA
basolateral plasma membrane	C		IDA	ISS
endosome	C		RCA	ISS ISS
protein binding	F		IPI IPI IPI IPI	ISS ISS
iron-sulfur cluster binding	F		IEA	IEA
nitric-oxide synthase regulator activity	F			ISS
kinase activity	F		IDA	ISS
protein heterodimerization activity	F			ISS
nucleotide binding	F		IEA
protein-tyrosine kinase activity	F		IEA IEA
MAP/ERK kinase kinase activity	F			ISS
receptor activity	F		IEA	IEA
epidermal growth factor receptor activity	F		IDA	TAS IDA ISS ISS
ATP binding	F		IEA IEA	IEA
signal transducer activity	F		IDA	ISS
actin filament binding	F			ISS
electron carrier activity	F		IEA	IEA
transmembrane receptor activity	F		ISS	ISS
double-stranded DNA binding	F			ISS
protein kinase activity	F		IEA
transferase activity	F		IEA
transmembrane receptor protein tyrosine kinase activity	F		IEA
protein amino acid phosphorylation	P		IEA	IEA
regulation of peptidyl-tyrosine phosphorylation	P		IMP	ISS ISS
protein amino acid autophosphorylation	P		IDA	ISS
positive regulation of MAPK activity	P			ISS
translation	P			IDA
protein insertion into membrane	P			ISS
neurite morphogenesis	P			IMP
cell proliferation	P		RCA	ISS ISS
transmembrane receptor protein tyrosine kinase signaling pathway	P		IEA
activation of MAPKK activity	P			IMP
cell morphogenesis	P		RCA	ISS
ossification	P			ISS
menstrual cycle	P			IMP
positive regulation of epithelial cell proliferation	P			ISS
negative regulation of progression through mitotic cell cycle	P			IMP
positive regulation of nitric oxide biosynthetic process	P			ISS
cell-cell adhesion	P			ISS
response to calcium ion	P			IMP
epidermal growth factor receptor signaling pathway	P		ISS IDA RCA IDA IGI	IDA ISS ISS
response to stress	P			ISS
cell surface receptor linked signal transduction	P		ISS	ISS
electron transport	P		IEA	IEA
signal transduction	P		IDA	IDA ISS
phospholipase C activation	P			ISS
protein kinase cascade	P			IDA
calcium-dependent phospholipase A2 activation	P			ISS
positive regulation of smooth muscle cell proliferation	P			IMP
astrocyte activation	P			IMP
regulation of nitric-oxide synthase activity	P			ISS
negative regulation of apoptosis	P			IMP
positive regulation of synaptic transmission, glutamatergic	P			IMP
positive regulation of phosphorylation	P			ISS
positive regulation of cell migration	P			ISS
positive regulation of cell proliferation	P		IGI ISS IDA	ISS

Cellular Component

Biological Process

Molecular Function

Phenotype (31)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
adipose tissue phenotype	MP		Un
craniofacial phenotype	MP		Un Un Un
skin/coat/nails phenotype	MP		Un Un Un Un Un Un Un Un
endocrine/exocrine gland phenotype	MP		Un Un
homeostasis/metabolism phenotype	MP		Un
pigmentation phenotype	MP		Un
embryogenesis phenotype	MP		Un Un Un Un
lethality-embryonic/perinatal	MP		Un Un Un Un Un Un Un
muscle phenotype	MP		Un
skeleton phenotype	MP		Un Un Un Un
lethality-postnatal	MP		Un Un Un Un
renal/urinary system phenotype	MP		Un Un
liver/biliary system phenotype	MP		Un
nervous system phenotype	MP		Un Un Un
growth/size phenotype	MP		Un Un Un Un Un Un
reproductive system phenotype	MP		Un Un
respiratory system phenotype	MP		Un Un Un Un
life span-post-weaning/aging	MP		Un
tumorigenesis	MP		Un
vision/eye phenotype	MP		Un Un Un Un Un Un
normal phenotype	MP		Un
cardiovascular system phenotype	MP		Un Un Un Un
digestive/alimentary phenotype	MP		Un Un Un Un
limbs/digits/tail phenotype	MP		Un
hearing/vestibular/ear phenotype	MP		Un
touch/vibrissae phenotype	MP		Un Un Un Un Un Un Un
abnormal atrioventricular valve morphology	N			ISS
abnormal semilunar valve morphology	N			ISS
renal fibrosis	N			IED
abnormal estrous cycle	N			IED
left ventricle hypertrophy	N			IED

Disease (5)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Hypertrophy, Left Ventricular	D			IED
Carcinoma, Non-Small-Cell Lung	D			ISS
Cardiomegaly	D			ISS
Diabetic Retinopathy	D			ISS
Hypertension	D			IEP

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
phosphatidylinositol 3 kinase-Akt signaling pathway	W			IMP
The extracellular signal-regulated RAF/MEK/ERK pathway	W			IMP
epidermal growth factor/neuregulin signaling pathway	W			IMP

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Glioma (05214)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
GnRH signaling pathway (04912)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Epithelial cell signaling in Helicobacter pylori infection (05120)	Present in KEGG pathway	Not present in KEGG pathway	Not present in KEGG pathway
Adherens junction (04520)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Calcium signaling pathway (04020)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Colorectal cancer (05210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Gap junction (04540)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Dorso-ventral axis formation (04320)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Cytokine-cytokine receptor interaction (04060)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Focal adhesion (04510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway