IpiRecord: IPI00752953

IPI00752953 - Nck2, KINASE ADAPTOR PROTEIN 2, FULL INSERT SEQUENCE.
Uniprot Accession: Q8BQ28
Uniprot ID: Q8BQ28_MOUSE
Mapping: Chr 1, 43390297 - 43515060
Entrez Gene: 17974
Entrez MapView: Geneprod
MGI: MGI:1306821
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8732)
Rat: Nck2_predicted, SIMILAR TO NON-CATALYTIC REGION OF TYROSINE KINASE ADAPTOR PROTEIN 2.
Mouse: Nck2, KINASE ADAPTOR PROTEIN 2, FULL INSERT SEQUENCE.
Human: NCK2, CYTOPLASMIC PROTEIN NCK2.
Human: NCK2, NCK ADAPTOR PROTEIN 2 ISOFORM B.

Annotations for Nck2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCNAS ISS 
vesicle membraneCIDA ISS 
kinase activityFIEA 
cytoskeletal adaptor activityFNAS ISS 
receptor signaling complex scaffold activityFNAS ISS 
protein bindingFIPI ISS 
negative regulation of cell proliferationPTAS RCA ISS ISS 
signal complex assemblyPNAS ISS 
intracellular signaling cascadePIEA RCA ISS 
lamellipodium biogenesisPIMP ISS 
T cell activationPNAS ISS 
regulation of epidermal growth factor receptor activityPTAS RCA ISS ISS 
signal transductionPRCA ISS 
epidermal growth factor receptor signaling pathwayPRCA ISS 
positive regulation of T cell proliferationPIMP ISS 
positive regulation of actin filament polymerizationPIMP ISS 
cell migrationPIMP ISS 
actin filament organizationPIMP ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn
normal phenotypeMPUn
growth/size phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pathogenic Escherichia coli infection - EHEC (05130)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Pathogenic Escherichia coli infection - EPEC (05131)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Axon guidance (04360)Present in KEGG pathway Present in KEGG pathwayNot present in KEGG pathway