| IPI00830323 - Smad3, MAD HOMOLOG 3. | |
|---|---|
| Uniprot Accession: A2CG45 | |
| Uniprot ID: A2CG45_MOUSE | |
| Mapping: Chr 9, 63444773 - 63556000 | |
| Entrez Gene: 17127 | |
| Entrez MapView: |
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| MGI: MGI:1201674 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8161) |
|---|
| Rat: Smad3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3. |
| Mouse: Smad3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3. |
| Mouse: Smad3, PUTATIVE UNCHARACTERIZED PROTEIN (FRAGMENT). |
| Mouse: Smad3, MAD HOMOLOG 3. |
| Mouse: Smad3, MAD HOMOLOG 3. |
| Mouse: Smad3, MAD HOMOLOG 3. |
| Human: SMAD3, SMAD3 PROTEIN. |
| Human: SMAD3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3. |
| Human: SMAD3, HSPC193. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| protein complex | C | IDA | ||
| transcription factor complex | C | IEA | ||
| plasma membrane | C | IEA | IDA | ISS IEA |
| intracellular | C | IC | IEA | IEA |
| nucleus | C | IEA | IDA IDA | ISS IDA IEA |
| cytoplasm | C | IEA | IEA | |
| transcription factor activity | F | TAS | IDA RCA | ISS |
| transcription activator activity | F | IEA | IDA IDA | ISS IEA |
| double-stranded DNA binding | F | IEA | IDA | ISS IEA |
| transcription factor binding | F | IEA | IPI | ISS IEA |
| protein binding | F | IPI IPI IPI IPI IPI | ISS IPI | |
| DNA binding | F | IDA | ||
| SMAD binding | F | IPI | ||
| regulation of transforming growth factor beta receptor signaling pathway | P | IEA | IDA | ISS IEA |
| transforming growth factor beta receptor signaling pathway | P | RCA | ISS | |
| regulation of epithelial cell proliferation | P | IEA | IMP | ISS IEA |
| paraxial mesoderm morphogenesis | P | IEA | IMP | ISS IEA |
| mesoderm formation | P | IEA | IMP | ISS IEA |
| positive regulation of transcription | P | IDA | ISS | |
| T cell activation | P | IEA | IMP | IEA |
| organ morphogenesis | P | IEA | ||
| regulation of binding | P | IEA | IDA | ISS IEA |
| transcription | P | IEA | IEA | IEA |
| regulation of transcription, DNA-dependent | P | RCA | ISS | |
| regulation of striated muscle development | P | IEA | IDA | ISS IEA |
| transcription from RNA polymerase II promoter | P | TAS | RCA | ISS |
| positive regulation of transcription, DNA-dependent | P | IDA | ISS | |
| positive regulation of transcription from RNA polymerase II promoter | P | IEA | IDA | ISS IEA |
| common-partner SMAD protein phosphorylation | P | IEA | ||
| regulation of immune response | P | IEA | IMP | IEA |
| SMAD protein complex assembly | P | IEA | ||
| negative regulation of transcription from RNA polymerase II promoter | P | IEA | IDA IDA | ISS IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| cellular phenotype | MP | Un Un | ||
| homeostasis/metabolism phenotype | MP | Un | ||
| embryogenesis phenotype | MP | Un | ||
| immune system phenotype | MP | Un Un | ||
| skeleton phenotype | MP | Un Un | ||
| tumorigenesis | MP | Un Un | ||
| cardiovascular system phenotype | MP | Un | ||
| digestive/alimentary phenotype | MP | Un | ||
| limbs/digits/tail phenotype | MP | Un | ||
| hematopoietic system phenotype | MP | Un | ||
| reproductive system phenotype | MP | Un | ||
| growth/size phenotype | MP | Un Un Un | ||
| life span-post-weaning/aging | MP | Un Un | ||
| liver/biliary system phenotype | MP | Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Colorectal Neoplasms, Hereditary Nonpolyposis | D | ISS |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| SMAD dependent signaling pathways | W | IDA | ||
| transforming growth factor-beta signaling pathway - SMAD dependent | W | IDA | ||
| activin signaling pathway | W | TAS |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Chronic myeloid leukemia (05220) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| TGF-beta signaling pathway (04350) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Cell cycle (04110) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Adherens junction (04520) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Wnt signaling pathway (04310) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Colorectal cancer (05210) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Pancreatic cancer (05212) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |