IpiRecord: IPI00831542

IPI00831542 - Smad3, MAD HOMOLOG 3.
Uniprot Accession: A2CG44
Uniprot ID: A2CG44_MOUSE
Mapping: Chr 9, 63444773 - 63556000
Entrez Gene: 17127
Entrez MapView: Geneprod
MGI: MGI:1201674
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8161)
Rat: Smad3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3.
Mouse: Smad3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3.
Mouse: Smad3, PUTATIVE UNCHARACTERIZED PROTEIN (FRAGMENT).
Mouse: Smad3, MAD HOMOLOG 3.
Mouse: Smad3, MAD HOMOLOG 3.
Mouse: Smad3, MAD HOMOLOG 3.
Human: SMAD3, SMAD3 PROTEIN.
Human: SMAD3, MOTHERS AGAINST DECAPENTAPLEGIC HOMOLOG 3.
Human: SMAD3, HSPC193.

Annotations for Smad3 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
protein complexCIDA 
transcription factor complexCIEA 
plasma membraneCIEA IDA ISS IEA 
intracellularCIC IEA IEA 
nucleusCIEA IDA IDA ISS IDA IEA 
cytoplasmCIEA IEA 
transcription factor activityFTAS IDA RCA ISS 
transcription activator activityFIEA IDA IDA ISS IEA 
double-stranded DNA bindingFIEA IDA ISS IEA 
transcription factor bindingFIEA IPI ISS IEA 
protein bindingFIPI IPI IPI IPI IPI ISS IPI 
DNA bindingFIDA 
SMAD bindingFIPI 
regulation of transforming growth factor beta receptor signaling pathwayPIEA IDA ISS IEA 
transforming growth factor beta receptor signaling pathwayPRCA ISS 
regulation of epithelial cell proliferationPIEA IMP ISS IEA 
paraxial mesoderm morphogenesisPIEA IMP ISS IEA 
mesoderm formationPIEA IMP ISS IEA 
positive regulation of transcriptionPIDA ISS 
T cell activationPIEA IMP IEA 
organ morphogenesisPIEA 
regulation of bindingPIEA IDA ISS IEA 
transcriptionPIEA IEA IEA 
regulation of transcription, DNA-dependentPRCA ISS 
regulation of striated muscle developmentPIEA IDA ISS IEA 
transcription from RNA polymerase II promoterPTAS RCA ISS 
positive regulation of transcription, DNA-dependentPIDA ISS 
positive regulation of transcription from RNA polymerase II promoterPIEA IDA ISS IEA 
common-partner SMAD protein phosphorylationPIEA 
regulation of immune responsePIEA IMP IEA 
SMAD protein complex assemblyPIEA 
negative regulation of transcription from RNA polymerase II promoterPIEA IDA IDA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (14)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
immune system phenotypeMPUn Un
skeleton phenotypeMPUn Un
tumorigenesisMPUn Un
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
limbs/digits/tail phenotypeMPUn
hematopoietic system phenotypeMPUn
reproductive system phenotypeMPUn
growth/size phenotypeMPUn Un Un
life span-post-weaning/agingMPUn Un
liver/biliary system phenotypeMPUn

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Colorectal Neoplasms, Hereditary NonpolyposisDISS

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
SMAD dependent signaling pathwaysWIDA
transforming growth factor-beta signaling pathway - SMAD dependentWIDA
activin signaling pathwayWTAS

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adherens junction (04520)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway