IpiRecord: IPI00857195

IPI00857195 - Itgav, INTEGRIN ALPHA V.
Uniprot Accession: A2AKI6
Uniprot ID: A2AKI6_MOUSE
Mapping: Chr 2, 83525354 - 83604646
Entrez Gene: 16410
Entrez MapView: Geneprod
MGI: MGI:96608
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_3375)
Rat: Itgav_predicted, 110 KDA PROTEIN.
Mouse: Itgav, INTEGRIN ALPHA-V PRECURSOR.
Mouse: Itgav, INTEGRIN ALPHA V.
Mouse: Itgav, INTEGRIN ALPHA V.
Mouse: Itgav, INTEGRIN ALPHA V.
Mouse: Itgav, INTEGRIN ALPHA V.
Rat: Itgav_predicted, SIMILAR TO INTEGRIN ALPHA-V PRECURSOR.
Rat: Itgav_predicted, 102 KDA PROTEIN.
Rat: Itgav_predicted, PROTEIN.
Rat: Itgav_predicted, SIMILAR TO INTEGRIN ALPHA-V PRECURSOR.
Rat: Itgav_predicted, 109 KDA PROTEIN.
Human: ITGAV, ISOFORM 1 OF INTEGRIN ALPHA-V PRECURSOR.
Human: ITGAV, ISOFORM 2 OF INTEGRIN ALPHA-V PRECURSOR.

Annotations for Itgav and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integrin complexCIEA ISS IC IEA 
plasma membraneCIDA 
membraneCIEA 
integral to membraneCIEA 
protein bindingFIEA ISS 
protein heterodimerization activityFIC 
receptor activityFIEA 
calcium ion bindingFIEA IEA 
peptide bindingFIDA 
positive regulation of MAPKKK cascadePIDA 
cell differentiationPIEA 
cellular calcium ion homeostasisPIDA 
cell-matrix adhesionPISS 
positive regulation of cell proliferationPIDA 
blood vessel developmentPIMP 
integrin-mediated signaling pathwayPIEA ISS IDA 
cell adhesionPIEA IEA ISS IDA IEA 
angiogenesisPIEA IEP 
cell migrationPIMP 
elevation of cytosolic calcium ion concentrationPIDA 
vasculogenesisPIEP 
multicellular organismal developmentPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (10)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
skeleton phenotypeMPUn
muscle phenotypeMPUn
nervous system phenotypeMPUn
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
growth/size phenotypeMPUn

Disease (11)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Corneal NeovascularizationDIED
Metabolic Syndrome XDISS
Coronary StenosisDISSIED
IschemiaDISSIED
Retinal NeovascularizationDISS
Cerebral HemorrhageDISS
Myocardial IschemiaDISS
HyperglycemiaDISS
Aortic Aneurysm, AbdominalDISS
HypertensionDIEP
Choroidal NeovascularizationDIED

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
integrin signaling pathwayWISSIDA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
ECM-receptor interaction (04512)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell adhesion molecules (CAMs) (04514)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway