IpiRecord: IPI00192415

IPI00192415 - Lta, LYMPHOTOXIN-ALPHA PRECURSOR.
Uniprot Accession: Q06332
Uniprot ID: TNFB_RAT
Mapping: Chr 20, 3657842 - 3659848
Entrez Gene: 25008
Entrez MapView: Geneprod
RGD: 3020
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_14297)
Rat: Lta, LYMPHOTOXIN-ALPHA PRECURSOR.
Mouse: Lta, LYMPHOTOXIN-ALPHA PRECURSOR.
Mouse: Lta, CLONE:F830035M07 PRODUCT:LYMPHOTOXIN A, FULL INSERT SEQUENCE.
Human: LTA, LYMPHOTOXIN-ALPHA PRECURSOR.
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 3.
Human: LTA, LYMPHOTOXIN ALPHA.
Human: LTA, LTA PROTEIN.
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 6 (FRAGMENT).
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 8 (FRAGMENT).
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 7 (FRAGMENT).
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 4 (FRAGMENT).
Human: LTA, LYMPHOTOXIN ALPHA TRANSCRIPT VARIANT 5 (FRAGMENT).

Annotations for Lta and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
extracellular spaceCIEA RCA ISS IEA 
membraneCIEA IEA IEA IEA 
cytokine activityFIEA IEA IEA 
tumor necrosis factor receptor bindingFIEA TAS TAS TAS TAS TAS TAS TAS ISS IEA 
cysteine-type endopeptidase activityFIEA 
lymph node developmentPIEA IMP IMP IMP IMP IMP ISS IEA 
inflammatory responsePTAS TAS TAS TAS TAS ISS 
transformed cell apoptosisPTAS TAS ISS 
cellular processPTAS 
humoral immune responsePIEA IMP ISS IEA 
positive regulation of apoptosisPIMP 
positive regulation of cell proliferationPTAS ISS 
response to lipopolysaccharidePIEP 
response to nutrientPIEP 
cell-cell signalingPTAS 
cell proliferationPTAS ISS 
induction of apoptosisPTAS 
immune responsePIEA IEA 
proteolysisPIEA 
signal transductionPTAS 
negative regulation of fibroblast proliferationPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
endocrine/exocrine gland phenotypeMPUn
life span-post-weaning/agingMPUn Un
immune system phenotypeMPUn Un Un Un Un Un
respiratory system phenotypeMPUn
liver/biliary system phenotypeMPUn
hematopoietic system phenotypeMPUn Un Un Un
digestive/alimentary phenotypeMPUn
abnormal response to transplantNIED

Disease (13)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
HypertriglyceridemiaDISSISS
Carotid Artery DiseasesDISS
Metabolic Syndrome XDISS
CardiomegalyDIED
Insulin ResistanceDISS
Myocardial InfarctionDISS ISS
ArteriosclerosisDISS
Encephalomyelitis, Experimental AutoimmuneDIEP
HyperinsulinemiaDISS
Coronary ArteriosclerosisDISS
GliomaDIED
HypertensionDISS
Cerebral InfarctionDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Antigen processing and presentation (04612)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Type I diabetes mellitus (04940)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway