IpiRecord: IPI00192561

IPI00192561 - Rb1, SIMILAR TO RETINOBLASTOMA-ASSOCIATED PROTEIN.
Uniprot Accession: P33568
Uniprot ID: RB_RAT
Mapping: Chr 15, 53828905 - 53961923
Entrez Gene: 24708
Entrez MapView: Geneprod
RGD: 3540
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_12532)
Rat: Rb1, SIMILAR TO RETINOBLASTOMA-ASSOCIATED PROTEIN.
Mouse: Rb1, RETINOBLASTOMA-ASSOCIATED PROTEIN.
Rat: Rb1, SIMILAR TO RETINOBLASTOMA-ASSOCIATED PROTEIN.
Human: RB1, RETINOBLASTOMA-ASSOCIATED PROTEIN.
Human: RB1, RB1 PROTEIN.

Annotations for Rb1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
chromatinCTAS ISS 
transcription factor complexCIDA ISS IEA 
spindleCIDA ISS IEA 
PML bodyCIDA ISS 
nucleusCTAS NAS IDA IDA IDA IDA IDA ISS ISS IEA 
transcription factor activityFTAS ISS 
kinase bindingFIDA ISS ISS 
androgen receptor bindingFNAS ISS 
protein bindingFIPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI IPI ISS ISS 
molecular_functionFND 
transcription coactivator activityFNAS ISS 
DNA bindingFIEA IEA 
transcription repressor activityFIDA ISS IEA 
transcription factor bindingFIPI IEA 
regulation of progression through cell cyclePIMP ISS 
cell cycle checkpointPTAS ISS 
negative regulation of transcription, DNA-dependentPIDA ISS 
negative regulation of cell proliferationPIMP IGI ISS IEA 
G1/S transition of mitotic cell cyclePIMP ISS IEA 
androgen receptor signaling pathwayPNAS ISS 
negative regulation of progression through cell cyclePIEA IMP ISS 
striated muscle cell differentiationPIGI ISS IEA 
negative regulation of protein kinase activityPIPI ISS ISS 
chromatin modificationPIEA IEA IEA 
M phasePNAS ISS 
negative regulation of cell growthPTAS ISS 
cell cycle arrestPIMP ISS IEA 
enucleate erythrocyte differentiationPIGI 
positive regulation of macrophage differentiationPIGI 
transcriptionPIEA IEA IEA 
regulation of lipid kinase activityPIDA ISS ISS 
cell cyclePIEA IEA IEA 
positive regulation of transcription, DNA-dependentPNAS ISS 
G1 phasePTAS ISS 
positive regulation of transcription from RNA polymerase II promoterPIDA IMP IGI ISS IEA 
cell divisionPIMP ISS IEA 
regulation of transcription, DNA-dependentPNAS IEA 
negative regulation of transcription from RNA polymerase II promoterPTAS IDA IGI ISS ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (28)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
skin/coat/nails phenotypeMPUn Un Un Un
cellular phenotypeMPUn Un Un Un Un Un
behavior/neurological phenotypeMPUn Un Un
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un Un
other phenotypeMPUn
embryogenesis phenotypeMPUn Un Un Un
lethality-embryonic/perinatalMPUn Un Un Un Un Un Un
immune system phenotypeMPUn Un Un Un
muscle phenotypeMPUn Un Un
skeleton phenotypeMPUn Un
lethality-postnatalMPUn Un
nervous system phenotypeMPUn Un Un Un Un Un
respiratory system phenotypeMPUn
vision/eye phenotypeMPUn Un Un Un Un Un
tumorigenesisMPUn Un Un Un Un Un
normal phenotypeMPUn
digestive/alimentary phenotypeMPUn
cardiovascular system phenotypeMPUn Un Un
reproductive system phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un Un Un Un
life span-post-weaning/agingMPUn Un Un
no phenotypic analysisMPUn Un
growth/size phenotypeMPUn Un Un Un
liver/biliary system phenotypeMPUn Un Un Un
pigmentation phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway