| IPI00194785 - Alox5, ARACHIDONATE 5-LIPOXYGENASE. | |
|---|---|
| Uniprot Accession: P12527 | |
| Uniprot ID: LOX5_RAT | |
| Mapping: Chr 4, 152610283 - 152657801 | |
| Entrez Gene: 25290 | |
| Entrez MapView: |
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| RGD: 2096 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4860) |
|---|
| Rat: Alox5, ARACHIDONATE 5-LIPOXYGENASE. |
| Mouse: Alox5, ARACHIDONATE 5-LIPOXYGENASE. |
| Mouse: Alox5, ARACHIDONATE 5-LIPOXYGENASE. |
| Human: ALOX5, ARACHIDONATE 5-LIPOXYGENASE. |
| Human: ALOX5, ARACHIDONATE 5-LIPOXYGENASE VARIANT (FRAGMENT). |
| Human: ALOX5, SIMILAR TO ARACHIDONATE 5-LIPOXYGENASE. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| sarcolemma | C | IDA | ||
| membrane | C | IEA | IEA | |
| nuclear envelope | C | TAS | ||
| nucleus | C | IEA | IDA | ISS IEA |
| cytoplasm | C | IEA | IDA | ISS IEA |
| calcium ion binding | F | IEA | IEA | IEA |
| metal ion binding | F | IEA | IEA IEA | |
| arachidonate 5-lipoxygenase activity | F | TAS | IEA | ISS IMP ISS IEA |
| lipoxygenase activity | F | IEA | IEA | IEA |
| protein binding | F | IPI IPI | TAS ISS IEA | |
| oxidoreductase activity | F | IEA | IEA | IEA |
| oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen | F | IEA IEA | ||
| iron ion binding | F | IEA | IEA IEA | IEA |
| electron transport | P | IEA | IEA | IEA |
| arachidonic acid metabolic process | P | IMP | ||
| lipoxygenase pathway | P | IMP | ||
| inflammatory response | P | IEA | IMP | ISS ISS IEA |
| leukotriene biosynthetic process | P | IEA | IEA | TAS IEA |
| leukotriene metabolic process | P | IEA | IMP | ISS |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| adipose tissue phenotype | MP | Un | ||
| homeostasis/metabolism phenotype | MP | Un | ||
| immune system phenotype | MP | Un Un | ||
| skeleton phenotype | MP | Un | ||
| cardiovascular system phenotype | MP | Un Un | ||
| hematopoietic system phenotype | MP | Un Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Hypertension, Pulmonary | D | ISS | ||
| Arteriosclerosis | D | ISS | ||
| Hypertension, Portal | D | IED | ||
| Reperfusion Injury | D | IEP | ||
| Aortic Aneurysm | D | ISS | ||
| Hypertension | D | IED |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| lipoxygenase mediated pathway of arachidonic acid metabolism | W | IMP | ||
| leukotriene metabolic pathway | W | TAS | ||
| eicosanoids metabolic pathway | W | IEA |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Arachidonic acid metabolism (00590) | Present in KEGG pathway | Not present in KEGG pathway | Present in KEGG pathway |
| Linoleic acid metabolism (00591) | Present in KEGG pathway | Not present in KEGG pathway | Present in KEGG pathway |