IpiRecord: IPI00194785

IPI00194785 - Alox5, ARACHIDONATE 5-LIPOXYGENASE.
Uniprot Accession: P12527
Uniprot ID: LOX5_RAT
Mapping: Chr 4, 152610283 - 152657801
Entrez Gene: 25290
Entrez MapView: Geneprod
RGD: 2096
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4860)
Rat: Alox5, ARACHIDONATE 5-LIPOXYGENASE.
Mouse: Alox5, ARACHIDONATE 5-LIPOXYGENASE.
Mouse: Alox5, ARACHIDONATE 5-LIPOXYGENASE.
Human: ALOX5, ARACHIDONATE 5-LIPOXYGENASE.
Human: ALOX5, ARACHIDONATE 5-LIPOXYGENASE VARIANT (FRAGMENT).
Human: ALOX5, SIMILAR TO ARACHIDONATE 5-LIPOXYGENASE.

Annotations for Alox5 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
sarcolemmaCIDA 
membraneCIEA IEA 
nuclear envelopeCTAS 
nucleusCIEA IDA ISS IEA 
cytoplasmCIEA IDA ISS IEA 
calcium ion bindingFIEA IEA IEA 
metal ion bindingFIEA IEA IEA 
arachidonate 5-lipoxygenase activityFTAS IEA ISS IMP ISS IEA 
lipoxygenase activityFIEA IEA IEA 
protein bindingFIPI IPI TAS ISS IEA 
oxidoreductase activityFIEA IEA IEA 
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygenFIEA IEA 
iron ion bindingFIEA IEA IEA IEA 
electron transportPIEA IEA IEA 
arachidonic acid metabolic processPIMP 
lipoxygenase pathwayPIMP 
inflammatory responsePIEA IMP ISS ISS IEA 
leukotriene biosynthetic processPIEA IEA TAS IEA 
leukotriene metabolic processPIEA IMP ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
adipose tissue phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn Un
skeleton phenotypeMPUn
cardiovascular system phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un

Disease (6)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Hypertension, PulmonaryDISS
ArteriosclerosisDISS
Hypertension, PortalDIED
Reperfusion InjuryDIEP
Aortic AneurysmDISS
HypertensionDIED

Pathway (3)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
lipoxygenase mediated pathway of arachidonic acid metabolismWIMP
leukotriene metabolic pathwayWTAS
eicosanoids metabolic pathwayWIEA

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Arachidonic acid metabolism (00590)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Linoleic acid metabolism (00591)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway