IpiRecord: IPI00198496

IPI00198496 - Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1.
Uniprot Accession: P43245
Uniprot ID: MDR1_RAT
Mapping: Chr 4, 21829422 - 21912527
Entrez Gene: 24646
Entrez MapView: Geneprod
RGD: 3318
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4304)
Rat: Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1.
Mouse: Abcb1b, MULTIDRUG RESISTANCE PROTEIN 1.
Rat: Abcb1b, ATP-BINDING CASSETTE PROTEIN B1B.
Rat: Abcb1b, 141 KDA PROTEIN.

Annotations for Abcb1b and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
integral to membraneCRCA IEA ISS ISS 
apical plasma membraneCIDA 
intercellular canaliculusCIDA ISS 
membrane fractionCISS 
membraneCIEA IDA 
Golgi membraneCIDA 
cell surfaceCISS 
xenobiotic-transporting ATPase activityFIEA IEA 
transporter activityFIDA ISS 
drug transporter activityFIMP 
nucleoside-triphosphatase activityFIEA 
ATPase activityFIEA IEA 
ATPase activity, coupled to transmembrane movement of substancesFIEA IEA ISS 
ATP bindingFIEA IEA IEA ISS ISS 
protein bindingFIPI 
hydrolase activityFIEA IEA 
nucleotide bindingFIEA IEA IEA 
establishment of blood-brain barrierPIMP 
drug transportPIMP 
response to ionizing radiationPIEP 
transportPIEA IEA IDA ISS 
response to steroid hormone stimulusPIEP 
response to drugPISS IMP 
response to arsenicPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
hematopoietic system phenotypeMPUn
seizuresNIED

Disease (11)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
HIV InfectionsDIED
CholestasisDIEP
Kidney Failure, ChronicDIED
Liver Neoplasms, ExperimentalDIEP
Colorectal NeoplasmsDIED
Diabetes Mellitus, ExperimentalDIED
Status EpilepticusDIEP
Brain IschemiaDIEP
EndotoxemiaDIEP
GliomaDIED
Epilepsy, Temporal LobeDIED

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
multidrug resistance protein mediated transport pathwayWIDA

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
ABC transporters - General (02010)Not present in KEGG pathwayPresent in KEGG pathwayPresent in KEGG pathway