IpiRecord: IPI00200391

IPI00200391 - Ppp2ca, ISOFORM.
Uniprot Accession: P63331
Uniprot ID: PP2AA_RAT
Mapping: Chr 10, 37621256 - 37641006
Entrez Gene: 24672
Entrez MapView: Geneprod
RGD: 3380
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_9422)
Rat: Ppp2ca, ISOFORM.
Mouse: Ppp2ca, ISOFORM.
Human: PPP2CA, ISOFORM.
Human: PPP2CA, SERINE/THREONINE PROTEIN PHOSPHATASE.

Annotations for Ppp2ca and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
plasma membraneCIEA IDA ISS 
microtubule cytoskeletonCNAS 
cytosolCTAS IDA ISS 
nucleusCNAS 
soluble fractionCNAS 
protein phosphatase type 2A complexCTAS 
mitochondrionCNAS 
cytoplasmCIEA IDA IDA ISS 
CTD phosphatase activityFRCA ISS 
protein heterodimerization activityFIPI ISS 
protein bindingFIPI IPI ISS 
protein phosphatase type 2C activityFRCA ISS 
metal ion bindingFIEA IEA IEA 
manganese ion bindingFIEA RCA ISS IEA 
myosin phosphatase activityFRCA ISS 
iron ion bindingFIEA IEA IEA 
protein C-terminus bindingFIPI 
protein phosphatase type 1 activityFRCA ISS 
protein phosphatase type 2A activityFTAS RCA TAS ISS IDA 
protein serine/threonine phosphatase activityFRCA ISS 
hydrolase activityFIEA RCA ISS IEA 
phosphoprotein phosphatase activityFIEA IEA IEA IEA 
ceramide metabolic processPNAS 
inactivation of MAPK activityPNAS 
protein amino acid dephosphorylationPTAS TAS TAS ISS IDA 
negative regulation of cell growthPNAS 
regulation of progression through cell cyclePNAS TAS TAS ISS 
regulation of DNA replicationPNAS 
induction of apoptosisPTAS 
regulation of growthPNAS 
regulation of cell differentiationPNAS 
RNA splicingPNAS 
response to organic substancePNAS 
regulation of transcriptionPNAS 
negative regulation of tyrosine phosphorylation of Stat3 proteinPNAS 
mesoderm developmentPIEA IMP ISS 
regulation of Wnt receptor signaling pathwayPNAS 
second-messenger-mediated signalingPNAS 
regulation of cell adhesionPNAS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (3)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
growth/size phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Long-term depression (04730)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Tight junction (04530)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway