IpiRecord: IPI00201424

IPI00201424 - Prkaa2, ALPHA-2.
Uniprot Accession: Q09137-1
Uniprot ID: AAPK2_RAT
Mapping: Chr 5, 126007672 - 126074012
Entrez Gene: 78975
Entrez MapView: Geneprod
RGD: 620893
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5560)
Rat: Prkaa2, ALPHA-2.
Mouse: Prkaa2, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2.
Rat: Prkaa2, ALPHA-2.
Human: PRKAA2, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-2.

Annotations for Prkaa2 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
protein complexCIDA 
AMP-activated protein kinase complexCIDA IMP 
nucleusCIEA IDA TAS ISS 
protein binding, bridgingFIDA 
protein bindingFIPI 
AMP-activated protein kinase activityFTAS IDA IMP ISS IMP IDA 
protein kinase activityFIEA IDA 
kinase activityFIEA 
ATP bindingFIEA IEA IEA IDA 
protein serine/threonine kinase activityFIEA IEA IEA IDA 
metal ion bindingFIEA 
transferase activityFIEA IEA 
magnesium ion bindingFIEA IEA 
nucleotide bindingFIEA IEA 
protein amino acid phosphorylationPTAS IEA IDA ISS IDA 
lipid biosynthetic processPIEA 
regulation of lipid metabolic processPIDA 
response to stressPTAS IDA ISS 
sterol biosynthetic processPIEA 
fatty acid biosynthetic processPIEA IEA 
cholesterol biosynthetic processPIEA IEA 
steroid biosynthetic processPIEA 
signal transductionPTAS ISS 
protein heterooligomerizationPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (6)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
muscle phenotypeMPUn
renal/urinary system phenotypeMPUn
impaired glucose toleranceNISS
insulin resistanceNISS
decreased insulin secretionNISS

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Diabetes Mellitus, Non-Insulin-DependentDISS
Insulin ResistanceDISS

Pathway (5)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
nicotinate and nicotinamide metabolic pathwayWIEA
inositol phosphate metabolic pathwayWIEA
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayWIDAISSISS
starch and sucrose metabolic pathwayWIEA
benzoate degradation pathway via CoA ligationWIEA

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Regulation of autophagy (04140)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
mTOR signaling pathway (04150)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adipocytokine signaling pathway (04920)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway