| IPI00203826 - Kras, ISOFORM 2A OF GTPASE KRAS PRECURSOR. | |
|---|---|
| Uniprot Accession: P08644-1 | |
| Uniprot ID: RASK_RAT | |
| Mapping: Chr 4, 182869242 - 182895106 | |
| Entrez Gene: 24525 | |
| Entrez MapView: |
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| RGD: 2981 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5111) |
|---|
| Rat: Kras, ISOFORM 2A OF GTPASE KRAS PRECURSOR. |
| Mouse: Kras, ISOFORM 2A OF GTPASE KRAS PRECURSOR. |
| Mouse: Kras, ISOFORM 2B OF GTPASE KRAS PRECURSOR. |
| Mouse: Kras, 4 KDA PROTEIN. |
| Mouse: Kras, 4 KDA PROTEIN. |
| Rat: Kras, ISOFORM 2B OF GTPASE KRAS PRECURSOR. |
| Human: KRAS, KRAS PROTEIN. |
| Human: KRAS, ISOFORM 2A OF GTPASE KRAS PRECURSOR. |
| Human: KRAS, ISOFORM 2B OF GTPASE KRAS PRECURSOR. |
| Human: KRAS, 8 KDA PROTEIN. |
| Human: KRAS, K-RAS PROTEIN. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| membrane fraction | C | IDA | ISS | |
| intracellular | C | IEA | ||
| membrane | C | IEA | ||
| lipid raft | C | IDA | ||
| GMP binding | F | IDA | ||
| GTP binding | F | IEA | IEA IEA | |
| protein binding | F | IPI | ||
| LRR domain binding | F | IDA | ||
| GTPase activity | F | TAS IGI | ISS | |
| GDP binding | F | IDA | ||
| nucleotide binding | F | IEA | IEA | |
| regulation of progression through cell cycle | P | IEA | ||
| activation of NF-kappaB transcription factor | P | IMP | ||
| regulation of synaptic transmission, GABAergic | P | IGI | ||
| striated muscle cell differentiation | P | IGI | ISS | |
| positive regulation of MAPK activity | P | IMP | ||
| regulation of long-term neuronal synaptic plasticity | P | IGI | ||
| actin cytoskeleton organization and biogenesis | P | IGI | ||
| positive regulation of nitric-oxide synthase activity | P | IMP | ||
| Ras protein signal transduction | P | IGI TAS | ISS | |
| visual learning | P | IGI | ||
| response to glucocorticoid stimulus | P | IEP IEP | ||
| response to mineralocorticoid stimulus | P | IEP | ||
| negative regulation of neuron apoptosis | P | IGI | ||
| cytokine and chemokine mediated signaling pathway | P | IMP | ||
| positive regulation of cell proliferation | P | IGI | ||
| positive regulation of Rac protein signal transduction | P | IGI | ||
| small GTPase mediated signal transduction | P | IEA | IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| skin/coat/nails phenotype | MP | Un Un Un | ||
| cellular phenotype | MP | Un Un Un Un Un | ||
| behavior/neurological phenotype | MP | Un | ||
| homeostasis/metabolism phenotype | MP | Un Un | ||
| endocrine/exocrine gland phenotype | MP | Un Un | ||
| immune system phenotype | MP | Un | ||
| embryogenesis phenotype | MP | Un Un Un Un | ||
| lethality-embryonic/perinatal | MP | Un Un Un Un Un | ||
| lethality-postnatal | MP | Un Un | ||
| muscle phenotype | MP | Un Un | ||
| nervous system phenotype | MP | Un Un | ||
| respiratory system phenotype | MP | Un Un | ||
| vision/eye phenotype | MP | Un Un | ||
| tumorigenesis | MP | Un Un Un | ||
| limbs/digits/tail phenotype | MP | Un | ||
| cardiovascular system phenotype | MP | Un Un Un Un Un | ||
| normal phenotype | MP | Un Un | ||
| digestive/alimentary phenotype | MP | Un Un | ||
| hematopoietic system phenotype | MP | Un Un Un | ||
| growth/size phenotype | MP | Un Un Un Un | ||
| liver/biliary system phenotype | MP | Un Un Un | ||
| life span-post-weaning/aging | MP | Un Un Un | ||
| no phenotypic analysis | MP | Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Pancreatic Neoplasms | D | ISS | ||
| Stomach Neoplasms | D | ISS | ||
| Abnormalities, Multiple | D | ISSISS | ||
| Kidney Failure, Chronic | D | IED | ||
| Breast Neoplasms | D | ISS | ||
| Lung Neoplasms | D | ISS | ||
| Endometrial Neoplasms | D | IAGP | ||
| Sarcoma, Experimental | D | IAGP | ||
| Noonan Syndrome | D | ISS | ||
| Multiple Myeloma | D | ISS | ||
| Bladder Neoplasms | D | ISS | ||
| Mental Retardation | D | ISSISS | ||
| Cardiomyopathy, Congestive | D | ISS | ||
| Astrocytoma | D | ISS | ||
| Leukemia, Myelocytic, Acute | D | ISS | ||
| Hypertension | D | ISS |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Glioma (05214) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| GnRH signaling pathway (04912) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| T cell receptor signaling pathway (04660) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term depression (04730) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Chronic myeloid leukemia (05220) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| B cell receptor signaling pathway (04662) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Fc epsilon RI signaling pathway (04664) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| MAPK signaling pathway (04010) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| VEGF signaling pathway (04370) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Tight junction (04530) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Colorectal cancer (05210) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Regulation of actin cytoskeleton (04810) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Axon guidance (04360) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Gap junction (04540) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Dorso-ventral axis formation (04320) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Pancreatic cancer (05212) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Insulin signaling pathway (04910) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Natural killer cell mediated cytotoxicity (04650) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term potentiation (04720) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |