IpiRecord: IPI00204259

IPI00204259 - Hmgcr, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE.
Uniprot Accession: P51639
Uniprot ID: HMDH_RAT
Mapping: Chr 2, 27127499 - 27149580
Entrez Gene: 25675
Entrez MapView: Geneprod
RGD: 2803
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2084)
Rat: Hmgcr, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE.
Mouse: Hmgcr, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE.
Human: HMGCR, ISOFORM 1 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE.
Human: HMGCR, ISOFORM 2 OF 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE.

Annotations for Hmgcr and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
microsomeCIDA IDA IDA ISS 
membrane fractionCISS 
membraneCIEA IEA 
integral to membraneCIEA IEA IEA 
endoplasmic reticulumCIEA IEA 
endoplasmic reticulum membraneCIEA IEA ISS 
peroxisomeCIEA 
hydroxymethylglutaryl-CoA reductase activityFIDA 
oxidoreductase activityFIEA IEA 
hydroxymethylglutaryl-CoA reductase (NADPH) activityFIDA IDA IDA IDA IDA IDA IDA IDA IEA ISS 
protein homodimerization activityFIDA 
sterol biosynthetic processPIEA 
negative regulation of MAPK activityPIGI 
gonad developmentPISS 
embryonic developmentPIMP IEA ISS 
lipid metabolic processPIEA IEA 
visual learningPIGI 
lipid biosynthetic processPIEA 
farnesyl diphosphate biosynthetic process, mevalonate pathwayPTAS 
biosynthetic processPIEA 
cholesterol biosynthetic processPIDA IDA IDA IEA IDA ISS 
germ cell migrationPISS 
steroid biosynthetic processPIEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
lethality-embryonic/perinatalMPUn
normal phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
steroid biosynthetic pathwayWIEA

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Biosynthesis of steroids (00100)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway