| IPI00204351 - Ppara, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA. | |
|---|---|
| Uniprot Accession: P37230 | |
| Uniprot ID: PPARA_RAT | |
| Mapping: Chr 7, 123729774 - 123807090 | |
| Entrez Gene: 25747 | |
| Entrez MapView: |
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| RGD: 3369 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_7344) |
|---|
| Rat: Ppara, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA. |
| Mouse: Ppara, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA. |
| Human: PPARA, PPARA PROTEIN. |
| Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA. |
| Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA. |
| Human: PPARA, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ALPHA (FRAGMENT). |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| nucleus | C | TAS IEA | TAS | ISS ISS IDA IEA |
| receptor activity | F | IEA | IDA | ISS |
| metal ion binding | F | IEA | IEA | IEA |
| steroid hormone receptor activity | F | IEA | TAS | TAS ISS IEA |
| transcription factor activity | F | IEA | IMP | IEA |
| protein binding | F | IPI IPI | ISS IPI | ISS ISS IPI IEA |
| protein heterodimerization activity | F | TAS | ||
| protein domain specific binding | F | IDA | ||
| DNA binding | F | IDA IDA | ISS | |
| ligand-regulated transcription factor activity | F | IDA | ||
| transcription activator activity | F | IEA | IDA | ISS IMP IEA |
| sequence-specific DNA binding | F | IEA | IDA | IEA |
| zinc ion binding | F | IEA | IEA IEA | IEA |
| ligand-dependent nuclear receptor activity | F | IEA | IEA | IMP IMP |
| glucose metabolic process | P | TAS | ISS | |
| lipid metabolic process | P | TAS TAS | TAS | ISS ISS |
| fatty acid metabolic process | P | IMP TAS | ISS ISS IMP IMP IMP | |
| positive regulation of transcription | P | IEA | IMP | ISS IEA |
| response to hypoxia | P | IDA | ||
| fatty acid transport | P | TAS | ISS | |
| transcription from RNA polymerase II promoter | P | TAS | ISS | |
| response to insulin stimulus | P | IMP | ||
| lipoprotein metabolic process | P | IMP | ||
| transcription | P | IEA | IEA | IEA |
| regulation of transcription, DNA-dependent | P | IEA | TAS | IDA ISS IEA |
| negative regulation of blood pressure | P | IMP | ||
| positive regulation of fatty acid beta-oxidation | P | TAS | ISS | |
| epidermis development | P | IEA | IMP | ISS IEA |
| regulation of fatty acid metabolic process | P | IEA | IMP | TAS ISS IEA |
| positive regulation of transcription from RNA polymerase II promoter | P | IEA | IDA | ISS IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| skin/coat/nails phenotype | MP | Un | ||
| adipose tissue phenotype | MP | Un | ||
| homeostasis/metabolism phenotype | MP | Un | ||
| immune system phenotype | MP | Un | ||
| muscle phenotype | MP | Un | ||
| cardiovascular system phenotype | MP | Un | ||
| growth/size phenotype | MP | Un | ||
| life span-post-weaning/aging | MP | Un | ||
| liver/biliary system phenotype | MP | Un |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Hypertrophy, Left Ventricular | D | ISS | ||
| Lipid Metabolism, Inborn Errors | D | ISS | ||
| Coronary Arteriosclerosis | D | ISS | ||
| Hypertension | D | IED |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| PPAR signaling pathway (03320) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Adipocytokine signaling pathway (04920) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |