IpiRecord: IPI00204483

IPI00204483 - Serpine1, PLASMINOGEN ACTIVATOR INHIBITOR 1 PRECURSOR.
Uniprot Accession: P20961
Uniprot ID: PAI1_RAT
Mapping: Chr 12, 20931996 - 20942374
Entrez Gene: 24617
Entrez MapView: Geneprod
RGD: 3249
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_10888)
Rat: Serpine1, PLASMINOGEN ACTIVATOR INHIBITOR 1 PRECURSOR.
Mouse: Serpine1, PLASMINOGEN ACTIVATOR INHIBITOR 1 PRECURSOR.
Human: SERPINE1, PLASMINOGEN ACTIVATOR INHIBITOR 1 PRECURSOR.

Annotations for Serpine1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
extracellular spaceCRCA ISS 
extracellular regionCNAS ISS 
soluble fractionCIDA 
protein bindingFIPI IPI IPI IPI ISS IEA 
serine-type endopeptidase inhibitor activityFIEA IDA ISS IEA TAS 
endopeptidase inhibitor activityFIEA 
plasminogen activator activityFIEA IEA IEA 
protease bindingFIPI ISS IEA 
wound healingPIMP 
negative regulation of proteolysisPTAS 
fibrinolysisPTAS ISS 
response to reactive oxygen speciesPIEP 
regulation of angiogenesisPIEA IDA ISS IEA 
glucose homeostasisPIEP 
tissue regenerationPIEP 
blood coagulationPTAS ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (10)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
adipose tissue phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
renal/urinary system phenotypeMPUn
respiratory system phenotypeMPUn
tumorigenesisMPUn
cardiovascular system phenotypeMPUn
normal phenotypeMPUn
hematopoietic system phenotypeMPUn
growth/size phenotypeMPUn

Disease (4)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Diabetes Mellitus, Non-Insulin-DependentDISS
Venous ThrombosisDISS
Coronary ArteriosclerosisDISS
Diabetic NephropathiesDIAGP

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
oxygen homeostasis pathwayWIEP

KEGG Pathway (1)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Complement and coagulation cascades (04610)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway