IpiRecord: IPI00206370

IPI00206370 - Cdkn2a, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORM 2.
Uniprot Accession: Q2I316
Uniprot ID: Q2I316_RAT
Mapping: Chr 5, 108908749 - 108916380
Entrez Gene: 25163
Entrez MapView: Geneprod
RGD: 2323
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5502)
Rat: Cdkn2a, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORM 2.
Mouse: Cdkn2a, ISOFORM 2 OF CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORMS 1/2.
Mouse: Cdkn2a, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORM 3.
Mouse: Cdkn2a, ISOFORM 1 OF CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORMS 1/2.
Rat: Cdkn2a, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORM 1.
Human: CDKN2A, CYCLIN-DEPENDENT KINASE INHIBITOR.
Human: CDKN2A, ISOFORM 3 OF CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORMS 1/2/3.
Human: CDKN2A, CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORM 4.
Human: CDKN2A, ISOFORM 2 OF CYCLIN-DEPENDENT KINASE INHIBITOR 2A, ISOFORMS 1/2/3.

Annotations for Cdkn2a and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
nucleoplasmCIEA IDA ISS 
cytoplasmCIEA IDA ISS 
nucleusCIEA IEA NAS IEA IDA 
cellular_componentCND 
nucleolusCIEA IDA IDA IDA IDA IDA ISS 
protein bindingFIPI IPI IPI IPI ISS 
kinase activityFIEA 
transcription factor activityFIDA RCA ISS 
cyclin-dependent protein kinase inhibitor activityFIEA IDA IDA TAS ISS 
DNA bindingFIEA RCA ISS IEA 
negative regulation of cyclin-dependent protein kinase activityPIEA IDA ISS 
negative regulation of immature T cell proliferation in the thymusPIMP 
negative regulation of progression through cell cyclePIEA TAS IEA 
rRNA processingPIEA IEA IEA 
cell cycle arrestPIEA IDA ISS 
apoptosisPIEA IEA IEA 
somatic stem cell divisionPIMP 
cell agingPIEA IDA ISS 
cell cyclePNAS IEA IEA 
negative regulation of B cell proliferationPIMP 
epidermis developmentPIEA IMP ISS 
regulation of cyclin-dependent protein kinase activityPIDA ISS 
transcriptionPIEA IEA IEA 
response to drugPIEP 
agingPIMP ISS IEP 
regulation of transcription, DNA-dependentPIEA IDA RCA ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (9)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
homeostasis/metabolism phenotypeMPUn
immune system phenotypeMPUn
lethality-embryonic/perinatalMPUn
nervous system phenotypeMPUn Un
vision/eye phenotypeMPUn Un
tumorigenesisMPUn Un Un Un Un Un Un
hematopoietic system phenotypeMPUn
life span-post-weaning/agingMPUn Un

Disease (8)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Kidney NeoplasmsDIAGP
Stomach NeoplasmsDIAGP
Lung NeoplasmsDIAGP
Carcinoma, HepatocellularDIAGPIEP
Tongue NeoplasmsDIAGP
MelanomaDISS
Esophageal NeoplasmsDIEP
Colonic NeoplasmsDIEP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Not present in KEGG pathwayPresent in KEGG pathway