IpiRecord: IPI00208889

IPI00208889 - Cd28, T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Uniprot Accession: P31042
Uniprot ID: CD28_RAT
Mapping: Chr 9, 59342273 - 59367743
Entrez Gene: 25660
Entrez MapView: Geneprod
RGD: 2299
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8759)
Rat: Cd28, T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Mouse: Cd28, T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Mouse: Cd28, CD28 ANTIGEN.
Mouse: Cd28, CLONE:5830411K06 PRODUCT:CD28 ANTIGEN, FULL INSERT SEQUENCE.
Human: CD28, ISOFORM 1 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, ISOFORM 2 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, ISOFORM 3 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, ISOFORM 4 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, ISOFORM 5 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, ISOFORM 6 OF T-CELL-SPECIFIC SURFACE GLYCOPROTEIN CD28 PRECURSOR.
Human: CD28, T-CELL-SPECIFIC SURFACE GLYCOPROTEIN.

Annotations for Cd28 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
plasma membraneCISS ISS IEA 
external side of plasma membraneCIDA ISS IMP ISS ISS IEA 
integral to plasma membraneCISS 
integral to membraneCRCA ISS IEA 
membraneCIEA IEA IEA 
lipid raftCIDA 
coreceptor activityFNAS ISS 
protein bindingFISS 
identical protein bindingFISS 
cell surface receptor linked signal transductionPISS 
positive regulation of protein biosynthetic processPISS 
positive regulation of mitosisPISS ISS ISS 
negative thymic T cell selectionPIMP ISS IEA 
immune responsePIEA IEA TAS IEA 
positive regulation of isotype switching to IgG isotypesPIMP ISS IEA 
humoral immune responsePISS 
T cell activationPIMP 
positive regulation of viral genome replicationPISS 
positive regulation of anti-apoptosisPISS 
positive regulation of T cell proliferationPISS IDA IDA IDA IMP ISS ISS ISS 
induction of apoptosis by extracellular signalsPIDA ISS IEA 
positive regulation of interleukin-2 biosynthetic processPISS IMP ISS ISS ISS 
cytokine biosynthetic processPISS 
T cell costimulationPIDA IDA IDA IMP ISS IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (4)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
endocrine/exocrine gland phenotypeMPUn
immune system phenotypeMPUn Un
digestive/alimentary phenotypeMPUn
hematopoietic system phenotypeMPUn Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
T cell receptor signaling pathway (04660)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell adhesion molecules (CAMs) (04514)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Type I diabetes mellitus (04940)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway