IpiRecord: IPI00210027
| IPI00210027 - Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. | |
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| Uniprot Accession: P29994-1 | |
| Uniprot ID: ITPR1_RAT | |
| Mapping: Chr 4, 143705360 - 144030051 | |
| Entrez Gene: 25262 | |
| Entrez MapView: |
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| RGD: 2933 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4847) |
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| Rat: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Mouse: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Rat: Itpr1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 2 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 3 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 4 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 5 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 6 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 7 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 8 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, ISOFORM 1 OF INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 1. |
| Human: ITPR1, 20 KDA PROTEIN. |
| Human: ITPR1, 10 KDA PROTEIN. |
Annotations for Itpr1 and orthologs
GO Annotation Table
Compiled GO Annotations (from IPI)
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| plasma membrane | C | IDA | ||
| integral to plasma membrane | C | ISS | ||
| integral to membrane | C | IEA | ||
| postsynaptic density | C | IDA | ||
| protein complex | C | IPI | ||
| lipid raft | C | IDA | ||
| membrane | C | IEA IEA | ||
| endoplasmic reticulum membrane | C | ISS IDA | ||
| secretory granule membrane | C | IDA | ||
| endoplasmic reticulum | C | TAS | ISS ISS | |
| inositol 1,4,5-triphosphate-sensitive calcium-release channel activity | F | IEA | ||
| calcium channel activity | F | IEA IEA | ||
| calcium ion transmembrane transporter activity | F | ISS | ||
| calcium ion binding | F | IEA | ||
| receptor activity | F | IEA | ||
| protein binding | F | IPI | ISS ISS IPI IDA | |
| ion channel activity | F | IEA IEA | ||
| inositol-1,4,5-triphosphate receptor activity | F | TAS | ISS ISS | |
| calcium ion transport | P | IEA IEA | ISS | |
| transport | P | IEA | ||
| elevation of cytosolic calcium ion concentration | P | IMP | ||
| ion transport | P | IEA IEA | ||
| signal transduction | P | ISS |
Cellular Component
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
Biological Process
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
Molecular Function
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
Phenotype (8)
Compiled Mammalian Phenotype Ontology Annotations (from IPI)
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| cellular phenotype | MP | Un | ||
| behavior/neurological phenotype | MP | Un Un Un | ||
| lethality-embryonic/perinatal | MP | Un | ||
| lethality-postnatal | MP | Un Un | ||
| muscle phenotype | MP | Un | ||
| nervous system phenotype | MP | Un Un | ||
| growth/size phenotype | MP | Un | ||
| life span-post-weaning/aging | MP | Un Un |
Disease (1)
Compiled Disease Ontology Annotations (from IPI)
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Cardiomyopathy, Congestive | D | ISS |
Pathway (0)
There are no Pathway Ontology annotations for this protein in the database
KEGG Pathway (6)
KEGG Pathways for this protein (from IPI)
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| GnRH signaling pathway (04912) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term depression (04730) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Calcium signaling pathway (04020) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Gap junction (04540) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term potentiation (04720) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Phosphatidylinositol signaling system (04070) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
© MCW Proteomics Center, 2006-2008
Supported by funds from the National Heart, Lung and Blood Institute