IpiRecord: IPI00211647

IPI00211647 - Cdkn1a, P21.
Uniprot Accession: Q64315
Uniprot ID: Q64315_RAT
Mapping: Chr 20, 7379386 - 7385595
Entrez Gene: 114851
Entrez MapView: Geneprod
RGD: 69328
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_14229)
Rat: Cdkn1a, P21.
Mouse: Cdkn1a, CYCLIN-DEPENDENT KINASE INHIBITOR 1.
Human: CDKN1A, CYCLIN-DEPENDENT KINASE INHIBITOR 1.
Human: CDKN1A, CYCLIN-DEPENDENT KINASE INHIBITOR ISOFORM.

Annotations for Cdkn1a and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytoplasmCIEA IEA 
nucleusCTAS IEA IDA ISS ISS IEA 
cytosolCIEA IDA 
cyclin-dependent protein kinase holoenzyme complexCIEA IPI ISS 
metal ion bindingFIEA IEA 
cyclin bindingFIEA IPI ISS 
protein kinase inhibitor activityFIEA 
protein kinase activityFNR ISS 
protein bindingFIPI IPI IPI ISS ISS 
cyclin-dependent protein kinase inhibitor activityFTAS IEA IDA ISS ISS IEA 
zinc ion bindingFIEA IEA 
kinase activityFIEA IEA IEA 
induction of apoptosis by intracellular signalsPTAS ISS 
positive regulation of B cell proliferationPIEA IGI ISS 
negative regulation of cyclin-dependent protein kinase activityPIEA IDA ISS 
cell cycle arrestPTAS IEA IDA ISS ISS IEA 
cell cyclePIEA IEA 
regulation of progression through cell cyclePIDA ISS 
negative regulation of cell proliferationPTAS IMP IMP ISS ISS 
regulation of cyclin-dependent protein kinase activityPISS 
negative regulation of apoptosisPIEA IMP ISS 
response to UVPIEA IMP ISS 
positive regulation of non-apoptotic programmed cell deathPIEA IMP ISS 
response to DNA damage stimulusPIEA IMP ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (23)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
cellular phenotypeMPUn Un
craniofacial phenotypeMPUn
endocrine/exocrine gland phenotypeMPUn
homeostasis/metabolism phenotypeMPUn Un
immune system phenotypeMPUn Un
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
skeleton phenotypeMPUn
lethality-postnatalMPUn
muscle phenotypeMPUn Un
renal/urinary system phenotypeMPUn
respiratory system phenotypeMPUn
vision/eye phenotypeMPUn Un
tumorigenesisMPUn Un Un
normal phenotypeMPUn
digestive/alimentary phenotypeMPUn
limbs/digits/tail phenotypeMPUn
reproductive system phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn
hematopoietic system phenotypeMPUn Un
growth/size phenotypeMPUn Un
life span-post-weaning/agingMPUn
liver/biliary system phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cell cycle (04110)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway