IpiRecord: IPI00212001

IPI00212001 - Tnfrsf1a, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A PRECURSOR.
Uniprot Accession: P22934
Uniprot ID: TNR1A_RAT
Mapping: Chr 4, 162172542 - 162185252
Entrez Gene: 25625
Entrez MapView: Geneprod
RGD: 621237
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_5048)
Rat: Tnfrsf1a, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A PRECURSOR.
Mouse: Tnfrsf1a, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A PRECURSOR.
Mouse: Tnfrsf1a, TNFRSF1A PROTEIN (FRAGMENT).
Mouse: Tnfrsf1a, PROTEIN.
Mouse: Tnfrsf1a, 7 KDA PROTEIN.
Mouse: Tnfrsf1a, 32 KDA PROTEIN.
Rat: Tnfrsf1a, 51 KDA PROTEIN.
Human: TNFRSF1A, TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 1A PRECURSOR.
Human: TNFRSF1A, 4 KDA PROTEIN.
Human: TNFRSF1A, 19 KDA PROTEIN.
Human: TNFRSF1A, 51 KDA PROTEIN.

Annotations for Tnfrsf1a and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
plasma membraneCTAS ISS 
membraneCIEA IEA IEA 
integral to membraneCIEA IEA 
lipid raftCIDA 
integral to plasma membraneCTAS ISS 
extracellular regionCNAS ISS 
protein bindingFIPI IPI IPI IEA IPI ISS 
protein complex bindingFIPI 
receptor activityFIEA IEA IEA IEA 
heme bindingFRCA ISS 
tumor necrosis factor receptor activityFTAS TAS TAS IMP NAS ISS ISS ISS 
electron carrier activityFRCA ISS 
positive regulation of angiogenesisPIMP 
positive regulation of inflammatory responsePISS IMP ISS ISS 
inflammatory responsePISS IMP IMP IEP ISS ISS 
defense responsePIMP ISS 
activation of MAPK activityPISS 
response to woundingPIEP 
response to lipopolysaccharidePIEP 
apoptosisPIEA IEA IEA 
prostaglandin metabolic processPISS TAS ISS ISS 
electron transportPRCA ISS 
cell surface receptor linked signal transductionPIMP ISS 
response to ethanolPIEP 
positive regulation of transcription from RNA polymerase II promoterPISS IMP ISS ISS 
cytokine and chemokine mediated signaling pathwayPISS IMP ISS ISS 
positive regulation of I-kappaB kinase/NF-kappaB cascadePIEP ISS 
signal transductionPIEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (13)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
endocrine/exocrine gland phenotypeMP#
homeostasis/metabolism phenotypeMP###
lethality-embryonic/perinatalMP#
immune system phenotypeMP#####
lethality-postnatalMP#
skeleton phenotypeMP#
nervous system phenotypeMP##
limbs/digits/tail phenotypeMP#
digestive/alimentary phenotypeMP#
hematopoietic system phenotypeMP#
growth/size phenotypeMP#
life span-post-weaning/agingMP##
liver/biliary system phenotypeMP#

Disease (12)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Brain InjuriesDIEP
ObesityDISS
Metabolic Syndrome XDISS
Spinal Cord InjuriesDIEP
IschemiaDIED
FeverDISS
Myocardial InfarctionDIED
Insulin ResistanceDISS
ArteriosclerosisDISS
CachexiaDIEP
Brain IschemiaDIED
Reperfusion InjuryDIEP

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Adipocytokine signaling pathway (04920)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Apoptosis (04210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway