IpiRecord: IPI00212319

IPI00212319 - App, ISOFORM APP770 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Uniprot Accession: P08592-1
Uniprot ID: A4_RAT
Mapping: Chr 11, 24457766 - 24693964
Entrez Gene: 54226
Entrez MapView: Geneprod
RGD: 2139
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_10350)
Rat: App, ISOFORM APP770 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Mouse: App, ISOFORM APP770 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Mouse: App, ISOFORM APP751 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Mouse: App, ISOFORM APP695 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Mouse: App, AMYLOID PROTEIN (FRAGMENT).
Rat: App, ISOFORM APP695 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Rat: App, APP PROTEIN.
Rat: App, 83 KDA PROTEIN.
Human: APP, ISOFORM APP770 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM APP305 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM L-APP677 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM L-APP696 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM APP714 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM L-APP733 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM APP639 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM APP695 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM L-APP752 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).
Human: APP, ISOFORM APP751 OF AMYLOID BETA A4 PROTEIN PRECURSOR (FRAGMENT).

Annotations for App and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
neuron projectionCIDA ISS 
Golgi apparatusCIDA ISS IDA 
cytoplasmCIDA ISS 
ciliary rootletCIDA ISS 
spindle midzoneCIDA ISS 
integral to membraneCIDA ISS IEA 
axonCIDA IDA ISS 
membrane fractionCIDA IDA ISS 
cytoplasmic vesicleCIDA IDA ISS 
perinuclear region of cytoplasmCIDA ISS 
coated pitCIEA 
apical part of cellCIDA ISS 
membraneCTAS IDA ISS 
neuromuscular junctionCIDA ISS 
iron ion bindingFIEA 
serine-type endopeptidase inhibitor activityFIEA IEA IEA 
protein bindingFIPI ISS IPI 
bindingFIEA 
endopeptidase inhibitor activityFIEA 
metal ion bindingFIEA 
heparin bindingFIEA 
protease activator activityFIDA 
zinc ion bindingFIEA 
copper ion bindingFIEA 
DNA bindingFIDA ISS 
apoptosisPIEA 
regulation of body sizePIMP ISS 
mRNA polyadenylationPIDA ISS 
extracellular matrix organization and biogenesisPIGI ISS 
neuron remodelingPIMP ISS 
adult locomotory behaviorPIMP IMP IMP IMP ISS 
G2 phase of mitotic cell cyclePIMP ISS 
suckling behaviorPIGI ISS 
cell adhesionPIEA 
axonogenesisPIMP ISS 
regulation of translationPIDA 
smooth endoplasmic reticulum calcium ion homeostasisPIGI ISS 
axon midline choice point recognitionPIMP ISS 
regulation of synapse structure and activityPIMP ISS 
collateral sprouting in the absence of injuryPIGI ISS 
dendrite developmentPIMP IGI IMP ISS 
forebrain developmentPIMP IMP ISS 
visual learningPIMP ISS 
induction of apoptosisPIDA 
cellular copper ion homeostasisPIMP IGI ISS 
endocytosisPIEA 
neurite developmentPIDA ISS 
positive regulation of progression through mitotic cell cyclePIMP ISS 
regulation of balancePIGI ISS 
axon cargo transportPIMP IMP ISS 
locomotory behaviorPIGI ISS 
mating behaviorPIGI ISS 
positive regulation of transcription from RNA polymerase II promoterPIDA IGI ISS 
Notch signaling pathwayPIEA 
synaptic growth at neuromuscular junctionPIGI ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (10)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
cellular phenotypeMPUn
behavior/neurological phenotypeMPUn Un Un
other phenotypeMPUn Un Un
lethality-postnatalMPUn Un
nervous system phenotypeMPUn Un Un Un Un Un
reproductive system phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn
life span-post-weaning/agingMPUn
growth/size phenotypeMPUn Un Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Alzheimer DiseaseDISS

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
Alzheimer disease pathwayWIEA

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Alzheimer's disease (05010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Neurodegenerative Disorders (01510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway