IpiRecord: IPI00212707

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
cellular_component	C		ND
cytoplasm	C	TAS
kinase inhibitor activity	F		IDA IDA	ISS IEA
protein kinase inhibitor activity	F	TAS
protein binding	F		IPI IPI IPI	ISS IEA
insulin-like growth factor receptor binding	F	IPI
protein kinase binding	F	IPI
ubiquitin cycle	P	IEA	IEA	IEA
intracellular signaling cascade	P	IEA	IEA	IEA
cytokine and chemokine mediated signaling pathway	P	ISS	IDA IDA IMP	ISS IEA
negative regulation of insulin receptor signaling pathway	P	ISS	IDA	ISS IEA
negative regulation of signal transduction	P		IEA
JAK-STAT cascade	P	TAS	IDA	ISS IEA
negative regulation of tyrosine phosphorylation of Stat3 protein	P	ISS	IDA	ISS IEA
fat cell differentiation	P		IMP	ISS IEA
regulation of protein amino acid phosphorylation	P	ISS	IDA	ISS IEA
regulation of cell growth	P	IEA	IEA	IEA
negative regulation of JAK-STAT cascade	P	ISS NAS	IMP	ISS IEA

Cellular Component

Biological Process

Molecular Function

Phenotype (11)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
endocrine/exocrine gland phenotype	MP		Un
immune system phenotype	MP		Un Un Un Un
lethality-postnatal	MP		Un Un Un Un
tumorigenesis	MP		Un
normal phenotype	MP		Un
cardiovascular system phenotype	MP		Un
digestive/alimentary phenotype	MP		Un
hematopoietic system phenotype	MP		Un Un Un Un
growth/size phenotype	MP		Un Un
life span-post-weaning/aging	MP		Un Un
liver/biliary system phenotype	MP		Un Un Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (2)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
insulin signaling pathway	W			ISS
JAK-STAT signaling pathway	W			ISS

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Jak-STAT signaling pathway (04630)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Type II diabetes mellitus (04930)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Insulin signaling pathway (04910)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway