IpiRecord: IPI00215402

IPI00215402 - Prkaa1, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1.
Uniprot Accession: P54645
Uniprot ID: AAPK1_RAT
Mapping: Chr 2, 54327815 - 54360462
Entrez Gene: 65248
Entrez MapView: Geneprod
RGD: 3387
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2210)
Rat: Prkaa1, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1.
Mouse: Prkaa1, PROTEIN KINASE, AMP-ACTIVATED, ALPHA 1 CATALYTIC SUBUNIT.
Human: PRKAA1, PRKAA1 PROTEIN.
Human: PRKAA1, PROTEIN KINASE, AMP-ACTIVATED, ALPHA 1 CATALYTIC SUBUNIT ISOFORM 2.
Human: PRKAA1, PROTEIN KINASE, AMP-ACTIVATED, ALPHA 1 CATALYTIC SUBUNIT ISOFORM 1.

Annotations for Prkaa1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
intracellularCIC ISS 
protein complexCIDA 
AMP-activated protein kinase complexCIDA IMP 
AMP-activated protein kinase activityFIDA IMP IMP IDA 
kinase activityFIEA 
protein kinase activityFIEA ISS 
nucleotide bindingFIEA IEA IEA 
protein bindingFIPI 
metal ion bindingFIEA 
protein C-terminus bindingFIPI 
magnesium ion bindingFIEA IEA IEA 
ATP bindingFIEA IEA IEA IDA IEA 
cAMP-dependent protein kinase activityFNAS ISS 
protein serine/threonine kinase activityFIEA IEA IEA IDA IEA 
transferase activityFIEA IEA IEA 
eukaryotic elongation factor-2 kinase activator activityFNAS 
activation of MAPK activityPNAS ISS 
fatty acid oxidationPIMP IEA ISS 
positive regulation of glucose importPNAS 
glucose metabolic processPIMP IEA ISS 
sterol biosynthetic processPIEA 
negative regulation of protein biosynthetic processPNAS 
response to hypoxiaPNAS ISS 
protein amino acid phosphorylationPIEA TAS IEA IDA NAS IDA 
lipid biosynthetic processPIEA 
fatty acid biosynthetic processPIEA IEA IEA 
positive regulation of cholesterol biosynthetic processPNAS ISS 
cholesterol biosynthetic processPIEA IEA IEA 
positive regulation of anti-apoptosisPNAS ISS 
signal transductionPTAS ISS 
steroid biosynthetic processPIEA 
positive regulation of gluconeogenesisPNAS 
negative regulation of glucosylceramide biosynthetic processPNAS ISS 
positive regulation of fatty acid oxidationPNAS 
protein heterooligomerizationPIDA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (1)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
muscle phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (5)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
nicotinate and nicotinamide metabolic pathwayWIEA
inositol phosphate metabolic pathwayWIEA
adenosine monophosphate-activated protein kinase (AMPK) signaling pathwayWIDAISSISS
starch and sucrose metabolic pathwayWIEA
benzoate degradation pathway via CoA ligationWIEA

KEGG Pathway (4)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Regulation of autophagy (04140)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
mTOR signaling pathway (04150)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Adipocytokine signaling pathway (04920)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway