| IPI00231247 - Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. | |
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| Uniprot Accession: Q01986 | |
| Uniprot ID: MP2K1_RAT | |
| Mapping: Chr 8, 68379077 - 68451583 | |
| Entrez Gene: 170851 | |
| Entrez MapView: |
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| RGD: 70495 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8074) |
|---|
| Rat: Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. |
| Mouse: Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. |
| Human: MAP2K1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1. |
| Human: MAP2K1, PROTEIN. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Golgi apparatus | C | IDA | ||
| cytosol | C | IDA | ||
| protein serine/threonine kinase activity | F | IEA | IEA IEA | IEA |
| protein-tyrosine kinase activity | F | IEA | IEA | IEA |
| ATP binding | F | IEA | IEA IEA | IEA |
| protein binding | F | IPI | ISS IDA IEA | |
| nucleotide binding | F | IEA | IEA | IEA |
| kinase activity | F | IEA | ||
| MAP kinase kinase activity | F | TAS | IMP | TAS ISS ISS IDA IEA |
| protein kinase activity | F | IEA | ||
| transferase activity | F | IEA | IEA | IEA |
| mitosis | P | IDA | ||
| cell proliferation | P | IDA | ||
| response to oxidative stress | P | IDA | ||
| protein amino acid phosphorylation | P | IEA | IEA | TAS IEA |
| neuron differentiation | P | IEA | IMP | ISS IEA |
| chemotaxis | P | TAS | ISS | |
| cell motility | P | TAS | ISS | |
| keratinocyte differentiation | P | IEA | IMP | ISS IEA |
| response to glucocorticoid stimulus | P | IDA | ||
| protein kinase cascade | P | TAS | ||
| signal transduction | P | TAS | ISS |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| skin/coat/nails phenotype | MP | Un | ||
| craniofacial phenotype | MP | Un | ||
| cellular phenotype | MP | Un | ||
| homeostasis/metabolism phenotype | MP | Un | ||
| embryogenesis phenotype | MP | Un | ||
| lethality-embryonic/perinatal | MP | Un Un | ||
| no phenotypic analysis | MP | Un | ||
| reproductive system phenotype | MP | Un | ||
| cardiovascular system phenotype | MP | Un | ||
| vision/eye phenotype | MP | Un | ||
| hearing/vestibular/ear phenotype | MP | Un | ||
| digestive/alimentary phenotype | MP | Un | ||
| growth/size phenotype | MP | Un Un | ||
| abnormal vasculogenesis | N | ISS | ||
| abnormal placental development | N | ISS | ||
| postnatal lethality | N | ISS | ||
| decreased cell number | N | ISS |
| DO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| Cardiovascular Abnormalities | D | ISS | ||
| Brain Ischemia | D | IPI |
| PW Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| The extracellular signal-regulated RAF/MEK/ERK pathway | W | TASIMP |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Glioma (05214) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| GnRH signaling pathway (04912) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term depression (04730) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Chronic myeloid leukemia (05220) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Toll-like receptor signaling pathway (04620) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Fc epsilon RI signaling pathway (04664) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| MAPK signaling pathway (04010) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| VEGF signaling pathway (04370) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Colorectal cancer (05210) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Regulation of actin cytoskeleton (04810) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Gap junction (04540) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Dorso-ventral axis formation (04320) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Pancreatic cancer (05212) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Insulin signaling pathway (04910) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Natural killer cell mediated cytotoxicity (04650) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Focal adhesion (04510) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Long-term potentiation (04720) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |