IpiRecord: IPI00231247

IPI00231247 - Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1.
Uniprot Accession: Q01986
Uniprot ID: MP2K1_RAT
Mapping: Chr 8, 68379077 - 68451583
Entrez Gene: 170851
Entrez MapView: Geneprod
RGD: 70495
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_8074)
Rat: Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1.
Mouse: Map2k1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1.
Human: MAP2K1, DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 1.
Human: MAP2K1, PROTEIN.

Annotations for Map2k1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
Golgi apparatusCIDA 
cytosolCIDA 
protein serine/threonine kinase activityFIEA IEA IEA IEA 
protein-tyrosine kinase activityFIEA IEA IEA 
ATP bindingFIEA IEA IEA IEA 
protein bindingFIPI ISS IDA IEA 
nucleotide bindingFIEA IEA IEA 
kinase activityFIEA 
MAP kinase kinase activityFTAS IMP TAS ISS ISS IDA IEA 
protein kinase activityFIEA 
transferase activityFIEA IEA IEA 
mitosisPIDA 
cell proliferationPIDA 
response to oxidative stressPIDA 
protein amino acid phosphorylationPIEA IEA TAS IEA 
neuron differentiationPIEA IMP ISS IEA 
chemotaxisPTAS ISS 
cell motilityPTAS ISS 
keratinocyte differentiationPIEA IMP ISS IEA 
response to glucocorticoid stimulusPIDA 
protein kinase cascadePTAS 
signal transductionPTAS ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
craniofacial phenotypeMPUn
cellular phenotypeMPUn
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn Un
no phenotypic analysisMPUn
reproductive system phenotypeMPUn
cardiovascular system phenotypeMPUn
vision/eye phenotypeMPUn
hearing/vestibular/ear phenotypeMPUn
digestive/alimentary phenotypeMPUn
growth/size phenotypeMPUn Un
abnormal vasculogenesisNISS
abnormal placental developmentNISS
postnatal lethalityNISS
decreased cell numberNISS

Disease (2)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
Cardiovascular AbnormalitiesDISS
Brain IschemiaDIPI

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
The extracellular signal-regulated RAF/MEK/ERK pathwayWTASIMP

KEGG Pathway (17)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
GnRH signaling pathway (04912)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Long-term depression (04730)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Chronic myeloid leukemia (05220)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Toll-like receptor signaling pathway (04620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Fc epsilon RI signaling pathway (04664)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
MAPK signaling pathway (04010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
VEGF signaling pathway (04370)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Colorectal cancer (05210)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Gap junction (04540)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Dorso-ventral axis formation (04320)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Long-term potentiation (04720)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway