IpiRecord: IPI00231683

IPI00231683 - Pklr, ISOFORM L-TYPE OF PYRUVATE KINASE ISOZYMES R/L.
Uniprot Accession: P12928-2
Uniprot ID: KPYR_RAT
Mapping: Chr 2, 181214402 - 181223512
Entrez Gene: 24651
Entrez MapView: Geneprod
RGD: 3336
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_2656)
Rat: Pklr, ISOFORM R-TYPE OF PYRUVATE KINASE ISOZYMES R/L.
Mouse: Pklr, PYRUVATE KINASE ISOZYMES R/L.
Mouse: Pklr, PYRUVATE KINASE LIVER AND RED BLOOD CELL ISOFORM 2.
Mouse: Pklr, 8 KDA PROTEIN.
Rat: Pklr, ISOFORM L-TYPE OF PYRUVATE KINASE ISOZYMES R/L.
Human: PKLR, ISOFORM R-TYPE OF PYRUVATE KINASE ISOZYMES R/L.
Human: PKLR, PYRUVATE KINASE L.
Human: PKLR, ISOFORM L-TYPE OF PYRUVATE KINASE ISOZYMES R/L.

Annotations for Pklr and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
cytosolCIDA 
cellular_componentCND 
soluble fractionCIDA 
kinase activityFIEA 
metal ion bindingFIEA 
potassium ion bindingFIEA IEA 
magnesium ion bindingFIEA IEA IEA 
pyruvate kinase activityFNAS IDA IDA ISS ISS IDA 
transferase activityFIEA IEA 
cellular response to insulin stimulusPIDA 
response to ATPPIDA 
response to hypoxiaPIEP 
response to nutrientPIEP 
carbohydrate metabolic processPIDA 
response to cAMPPIDA 
response to lithium ionPIDA 
response to other organismPIMP ISS 
response to organic cyclic substancePIEP 
glycolysisPNAS IEA IEA 
response to metal ionPIEP 
response to heatPIDA 
response to glucose stimulusPIEP 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (2)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
immune system phenotypeMPUn
hematopoietic system phenotypeMPUn

Disease (7)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
ObesityDISS
Diabetes Mellitus, ExperimentalDIEP
Insulin ResistanceDISS
HyperinsulinemiaDISS
BurnsDIED
Reperfusion InjuryDIEP
HyperglycemiaDIEP

Pathway (4)

Compiled Pathway Ontology Annotations (from IPI)

PW Term Aspect Human Mouse Rat
glycolysis/gluconeogenesis pathwayWIEA
pyruvate metabolic pathwayWIEA
purine metabolic pathwayWIEA
carbon fixation pathwayWIEA

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Purine metabolism (00230)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Glycolysis / Gluconeogenesis (00010)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Type II diabetes mellitus (04930)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Carbon fixation (00710)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pyruvate metabolism (00620)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Insulin signaling pathway (04910)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Maturity onset diabetes of the young (04950)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway