IpiRecord: IPI00327408

IPI00327408 - Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR.
Uniprot Accession: P01134
Uniprot ID: TGFA_RAT
Mapping: Chr 4, 120355649 - 120435178
Entrez Gene: 24827
Entrez MapView: Geneprod
RGD: 3849
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4827)
Rat: Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR.
Mouse: Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR.
Mouse: Tgfa, TGFA PROTEIN.
Rat: Tgfa, 17 KDA PROTEIN.
Human: TGFA, TRANSFORMING GROWTH FACTOR-ALPHA VARIANT I.
Human: TGFA, TRANSFORMING GROWTH FACTOR, ALPHA ISOFORM 2.

Annotations for Tgfa and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
plasma membraneCNAS ISS 
integral to membraneCRCA ISS IEA 
integral to plasma membraneCNR TAS ISS 
extracellular spaceCNR IDA ISS 
membraneCIEA IEA 
nucleusCIDA 
soluble fractionCNR ISS 
protein bindingFISS 
MAP kinase kinase activityFIDA ISS 
epidermal growth factor receptor bindingFISS TAS TAS 
signal transducer activityFTAS TAS ISS 
glycoprotein bindingFIEA IDA ISS IEA 
epidermal growth factor receptor activating ligand activityFIDA ISS ISS 
growth factor activityFIDA IEA TAS ISS 
PDZ domain bindingFISS 
protein domain specific bindingFISS 
activation of MAPK activityPIDA ISS 
hair follicle morphogenesisPISS 
positive regulation of epidermal growth factor receptor activityPIDA ISS 
positive regulation of mitosisPIDA ISS 
cell proliferationPTAS IEA ISS IEA 
cytosolic calcium ion homeostasisPIMP 
cell-cell signalingPISS 
negative regulation of neuron apoptosisPIMP 
positive regulation of epithelial cell proliferationPIDA ISS 
epidermal growth factor receptor signaling pathwayPTAS 
positive regulation of protein amino acid phosphorylationPIMP 
positive regulation of cell proliferationPIMP 
anti-apoptosisPIDA 
angiogenesisPIEA IDA ISS IEA 
neuroprotectionPIMP 
wound healing, spreading of epidermal cellsPISS 
re-entry into mitotic cell cyclePISS 
regulation of progression through cell cyclePIEA IEA IEA 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

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Phenotype (13)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
craniofacial phenotypeMPUn
adipose tissue phenotypeMPUn
skin/coat/nails phenotypeMPUn Un Un
endocrine/exocrine gland phenotypeMPUn
immune system phenotypeMPUn Un
skeleton phenotypeMPUn
muscle phenotypeMPUn
touch/vibrissae phenotypeMPUn Un Un
vision/eye phenotypeMPUn Un Un
cardiovascular system phenotypeMPUn
digestive/alimentary phenotypeMPUn
reproductive system phenotypeMPUn
growth/size phenotypeMPUn Un

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (2)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Glioma (05214)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pancreatic cancer (05212)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway