| IPI00327408 - Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR. | |
|---|---|
| Uniprot Accession: P01134 | |
| Uniprot ID: TGFA_RAT | |
| Mapping: Chr 4, 120355649 - 120435178 | |
| Entrez Gene: 24827 | |
| Entrez MapView: |
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| RGD: 3849 | |
| +All IPI Database Cross References | |
| IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_4827) |
|---|
| Rat: Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR. |
| Mouse: Tgfa, PROTRANSFORMING GROWTH FACTOR ALPHA PRECURSOR. |
| Mouse: Tgfa, TGFA PROTEIN. |
| Rat: Tgfa, 17 KDA PROTEIN. |
| Human: TGFA, TRANSFORMING GROWTH FACTOR-ALPHA VARIANT I. |
| Human: TGFA, TRANSFORMING GROWTH FACTOR, ALPHA ISOFORM 2. |
| GO Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| plasma membrane | C | NAS | ISS | |
| integral to membrane | C | RCA | ISS IEA | |
| integral to plasma membrane | C | NR | TAS ISS | |
| extracellular space | C | NR | IDA ISS | |
| membrane | C | IEA | IEA | |
| nucleus | C | IDA | ||
| soluble fraction | C | NR | ISS | |
| protein binding | F | ISS | ||
| MAP kinase kinase activity | F | IDA | ISS | |
| epidermal growth factor receptor binding | F | ISS TAS TAS | ||
| signal transducer activity | F | TAS TAS | ISS | |
| glycoprotein binding | F | IEA | IDA | ISS IEA |
| epidermal growth factor receptor activating ligand activity | F | IDA | ISS ISS | |
| growth factor activity | F | IDA | IEA | TAS ISS |
| PDZ domain binding | F | ISS | ||
| protein domain specific binding | F | ISS | ||
| activation of MAPK activity | P | IDA | ISS | |
| hair follicle morphogenesis | P | ISS | ||
| positive regulation of epidermal growth factor receptor activity | P | IDA | ISS | |
| positive regulation of mitosis | P | IDA | ISS | |
| cell proliferation | P | TAS | IEA | ISS IEA |
| cytosolic calcium ion homeostasis | P | IMP | ||
| cell-cell signaling | P | ISS | ||
| negative regulation of neuron apoptosis | P | IMP | ||
| positive regulation of epithelial cell proliferation | P | IDA | ISS | |
| epidermal growth factor receptor signaling pathway | P | TAS | ||
| positive regulation of protein amino acid phosphorylation | P | IMP | ||
| positive regulation of cell proliferation | P | IMP | ||
| anti-apoptosis | P | IDA | ||
| angiogenesis | P | IEA | IDA | ISS IEA |
| neuroprotection | P | IMP | ||
| wound healing, spreading of epidermal cells | P | ISS | ||
| re-entry into mitotic cell cycle | P | ISS | ||
| regulation of progression through cell cycle | P | IEA | IEA | IEA |
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| GO Graph Color Key: | Rat | Mouse | Human | Rat & Mouse | Mouse & Human | Rat & Human | Rat, Mouse & Human |
SVG image
| MP Term | Aspect | Human | Mouse | Rat |
|---|---|---|---|---|
| craniofacial phenotype | MP | Un | ||
| adipose tissue phenotype | MP | Un | ||
| skin/coat/nails phenotype | MP | Un Un Un | ||
| endocrine/exocrine gland phenotype | MP | Un | ||
| immune system phenotype | MP | Un Un | ||
| skeleton phenotype | MP | Un | ||
| muscle phenotype | MP | Un | ||
| touch/vibrissae phenotype | MP | Un Un Un | ||
| vision/eye phenotype | MP | Un Un Un | ||
| cardiovascular system phenotype | MP | Un | ||
| digestive/alimentary phenotype | MP | Un | ||
| reproductive system phenotype | MP | Un | ||
| growth/size phenotype | MP | Un Un |
| KEGG Pathway | Human | Mouse | Rat |
|---|---|---|---|
| Glioma (05214) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |
| Pancreatic cancer (05212) | Present in KEGG pathway | Present in KEGG pathway | Present in KEGG pathway |