IpiRecord: IPI00373550

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term	Aspect	Human	Mouse	Rat
plasma membrane	C	IEA	IDA	ISS
cytoplasm	C	IEA	IDA	ISS
intracellular	C		RCA	ISS
nucleus	C		RCA	ISS
protein heterodimerization activity	F			IPI
kinase activity	F		IEA
protein binding	F	IPI		IPI
MAP kinase kinase kinase activity	F			IMP
diacylglycerol binding	F	IEA
receptor signaling protein activity	F	IEA	IEA	IEA
ATP binding	F	IEA	IEA IEA	IEA
protein serine/threonine kinase activity	F	IEA	IEA IEA	IEA IDA
metal ion binding	F	IEA	IEA
protein-tyrosine kinase activity	F			ISS
zinc ion binding	F	IEA	RCA	ISS
transferase activity	F	IEA	IEA	IEA
nucleotide binding	F	IEA	IEA	IEA
DNA binding	F		RCA	ISS
protein kinase activity	F		IEA
mitogen-activated protein kinase kinase binding	F			IMP
protein amino acid phosphorylation	P	TAS	IEA	IEA IDA IMP ISS
intracellular signaling cascade	P	IEA	IEA	IEA
regulation of transcription, DNA-dependent	P		RCA	ISS
anti-apoptosis	P	TAS		ISS
organ morphogenesis	P	TAS		ISS
signal transduction	P		IEA

Cellular Component

Biological Process

Molecular Function

Phenotype (17)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term	Aspect	Human	Mouse	Rat
cellular phenotype	MP		Un
behavior/neurological phenotype	MP		Un Un Un
endocrine/exocrine gland phenotype	MP		Un Un Un
homeostasis/metabolism phenotype	MP		Un Un Un
immune system phenotype	MP		Un Un
embryogenesis phenotype	MP		Un Un Un Un
lethality-embryonic/perinatal	MP		Un Un Un Un Un Un
lethality-postnatal	MP		Un Un Un
nervous system phenotype	MP		Un Un Un Un Un
respiratory system phenotype	MP		Un
tumorigenesis	MP		Un Un
cardiovascular system phenotype	MP		Un
normal phenotype	MP		Un Un Un
hematopoietic system phenotype	MP		Un Un
liver/biliary system phenotype	MP		Un
growth/size phenotype	MP		Un Un Un Un Un
life span-post-weaning/aging	MP		Un Un Un

Disease (1)

Compiled Disease Ontology Annotations (from IPI)

DO Term	Aspect	Human	Mouse	Rat
Melanoma	D			ISS

Pathway (1)

Compiled Pathway Ontology Annotations (from IPI)

PW Term	Aspect	Human	Mouse	Rat
The extracellular signal-regulated RAF/MEK/ERK pathway	W			IMPIMP

KEGG Pathway (13)

KEGG Pathways for this protein (from IPI)

KEGG Pathway	Human	Mouse	Rat
Glioma (05214)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Long-term depression (04730)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Chronic myeloid leukemia (05220)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
mTOR signaling pathway (04150)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
MAPK signaling pathway (04010)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Colorectal cancer (05210)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Regulation of actin cytoskeleton (04810)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Dorso-ventral axis formation (04320)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Pancreatic cancer (05212)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Insulin signaling pathway (04910)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Natural killer cell mediated cytotoxicity (04650)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Focal adhesion (04510)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway
Long-term potentiation (04720)	Present in KEGG pathway	Present in KEGG pathway	Present in KEGG pathway