IpiRecord: IPI00418087

IPI00418087 - Rock1, ISOFORM 2 OF RHO-ASSOCIATED PROTEIN KINASE 1.
Uniprot Accession: Q63644-2
Uniprot ID: ROCK1_RAT
Mapping: Chr 18, 1366989 - 1511865
Entrez Gene: 81762
Entrez MapView: Geneprod
RGD: 620424
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_13443)
Rat: Rock1, ISOFORM 1 OF RHO-ASSOCIATED PROTEIN KINASE 1.
Mouse: Rock1, ISOFORM 1 OF RHO-ASSOCIATED PROTEIN KINASE 1.
Mouse: Rock1, ISOFORM 2 OF RHO-ASSOCIATED PROTEIN KINASE 1.
Rat: Rock1, ISOFORM 2 OF RHO-ASSOCIATED PROTEIN KINASE 1.
Rat: Rock1, 158 KDA PROTEIN.
Human: ROCK1, RHO-ASSOCIATED PROTEIN KINASE 1.
Human: ROCK1, 20 KDA PROTEIN.
Human: ROCK1, 158 KDA PROTEIN.
Human: ROCK1, 22 KDA PROTEIN.
Human: ROCK1, 9 KDA PROTEIN.
Human: ROCK1, 11 KDA PROTEIN.
Human: ROCK1, ROCK1 PROTEIN.

Annotations for Rock1 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
microtubuleCISS 
Golgi apparatusCIEA IEA 
cytoskeletonCIEA IEA 
membraneCIEA IEA 
intracellularCIEA IEA 
cytoplasmCIEA IEA 
structural molecule activityFRCA ISS 
diacylglycerol bindingFIEA IEA 
GTP-Rho bindingFIMP 
identical protein bindingFIPI 
nucleotide bindingFIEA IEA 
protein serine/threonine kinase activityFTAS IEA IEA IEA NAS ISS 
protein-tyrosine kinase activityFISS 
metal ion bindingFIEA IEA 
zinc ion bindingFIEA IEA 
ATP bindingFIEA IEA IEA 
transferase activityFIEA IEA 
protein bindingFIEA IPI 
protein kinase activityFIEA IEA 
kinase activityFIEA 
protein amino acid phosphorylationPTAS IEA IEA ISS 
actin cytoskeleton organization and biogenesisPTAS IGI ISS 
cytokinesisPIEA IEA 
apoptosisPIEA IEA 
Rho protein signal transductionPTAS ISS 
intracellular signaling cascadePIEA IEA 
signal transductionPIEA IEA 
negative regulation of neuron apoptosisPIEA IMP ISS 
cytoskeleton organization and biogenesisPIMP 
microtubule-based movementPISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (8)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
skin/coat/nails phenotypeMPUn
immune system phenotypeMPUn
embryogenesis phenotypeMPUn
lethality-embryonic/perinatalMPUn
lethality-postnatalMPUn
vision/eye phenotypeMPUn
normal phenotypeMPUn
cardiovascular system phenotypeMPUn

Disease (0)

There are no Disease Ontology annotations for this protein in the database

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (0)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Pathogenic Escherichia coli infection - EHEC (05130)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
TGF-beta signaling pathway (04350)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Pathogenic Escherichia coli infection - EPEC (05131)Present in KEGG pathway Not present in KEGG pathwayNot present in KEGG pathway
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Wnt signaling pathway (04310)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Regulation of actin cytoskeleton (04810)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Axon guidance (04360)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Focal adhesion (04510)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway