IpiRecord: IPI00554141

IPI00554141 - Cxcr4, C-X-C CHEMOKINE RECEPTOR TYPE 4.
Uniprot Accession: Q62973
Uniprot ID: Q62973_RAT
Mapping: Chr 13, 41308286 - 41312170
Entrez Gene: 60628
Entrez MapView: Geneprod
RGD: 620465
+All IPI Database Cross References
IPI records in this ortholog cluster (Cluster: MGI_ORTHOLOGY_11222)
Rat: Cxcr4, C-X-C CHEMOKINE RECEPTOR TYPE 4.
Mouse: Cxcr4, ISOFORM CXCR4-B OF C-X-C CHEMOKINE RECEPTOR TYPE 4.
Mouse: Cxcr4, CHEMOKINE RECEPTOR 4.
Mouse: Cxcr4, CHEMOKINE (C-X-C MOTIF) RECEPTOR 4.
Rat: Cxcr4, CXC CHEMOKINE RECEPTOR.
Human: CXCR4, ISOFORM 1 OF C-X-C CHEMOKINE RECEPTOR TYPE 4.
Human: CXCR4, ISOFORM 2 OF C-X-C CHEMOKINE RECEPTOR TYPE 4.

Annotations for Cxcr4 and orthologs

GO Annotation Table

Compiled GO Annotations (from IPI)

GO Term Aspect Human Mouse Rat
growth coneCIDA ISS 
integral to membraneCRCA IEA ISS TAS 
membraneCIEA IEA 
endosomeCIDA 
purinergic nucleotide receptor activity, G-protein coupledFRCA ISS 
rhodopsin-like receptor activityFIEA IEA 
receptor activityFIEA IEA 
G-protein coupled receptor activityFIEA 
C-C chemokine receptor activityFIEA IEA TAS 
chemokine receptor activityFIEA 
C-X-C chemokine receptor activityFRCA IEA TAS ISS 
signal transducer activityFIEA 
motor axon guidancePIMP ISS 
T cell proliferationPIMP ISS 
ameboidal cell migrationPIMP ISS 
defense responsePIEA 
cardiac muscle contractionPIMP 
neuron recognitionPIEP 
neuron migrationPIDA IDA ISS IMP 
regulation of cell migrationPIMP IMP IGI ISS 
G-protein coupled receptor protein signaling pathwayPIEA IEA IEA 
regulation of calcium ion transportPIMP 
epithelial cell developmentPIMP 
chemotaxisPIEA 
nervous system developmentPTAS 
germ cell migrationPIMP ISS 
germ cell developmentPIMP ISS 
signal transductionPIEA IEA 
organ morphogenesisPTAS 
regulation of programmed cell deathPIMP 
cell migrationPIMP 
regulation of chemotaxisPIMP 
brain developmentPIMP ISS ISS 
patterning of blood vesselsPIMP ISS 

Cellular Component

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Biological Process

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Molecular Function

GO Graph Color Key: Rat Mouse Human Rat & Mouse Mouse & Human Rat & Human Rat, Mouse & Human

SVG image

Phenotype (13)

Compiled Mammalian Phenotype Ontology Annotations (from IPI)

MP Term Aspect Human Mouse Rat
homeostasis/metabolism phenotypeMPUn
embryogenesis phenotypeMPUn
immune system phenotypeMPUn Un Un Un Un
lethality-embryonic/perinatalMPUn Un Un
muscle phenotypeMPUn
renal/urinary system phenotypeMPUn
nervous system phenotypeMPUn Un
respiratory system phenotypeMPUn
cardiovascular system phenotypeMPUn Un Un
digestive/alimentary phenotypeMPUn Un
reproductive system phenotypeMPUn Un
hematopoietic system phenotypeMPUn Un Un Un Un
growth/size phenotypeMPUn Un

Disease (3)

Compiled Disease Ontology Annotations (from IPI)

DO Term Aspect Human Mouse Rat
WartsDISS
NeutropeniaDISS
AgammaglobulinemiaDISS

Pathway (0)

There are no Pathway Ontology annotations for this protein in the database

KEGG Pathway (3)

KEGG Pathways for this protein (from IPI)

KEGG Pathway Human Mouse Rat
Leukocyte transendothelial migration (04670)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Axon guidance (04360)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway
Cytokine-cytokine receptor interaction (04060)Present in KEGG pathway Present in KEGG pathwayPresent in KEGG pathway