KEGG ID: 00363
KEGG Diagram for Bisphenol A degradation
There are 4 IPI Records from this pathway found in Rattus norvegicus.
Location of Bisphenol A degradation proteins on Rat Genome
| IPI Record | Position |
|---|---|
| 1: Adi1 | 6:46552589-46559553 |
| 2: Hsd3b7 | 1:187085808-187089078 |
| 3: Pon1 | 4:29936318-29964862 |
| 4: Pon2 | 4:30033229-30068643 |
There are 4 IPI Records from this pathway found in Mus musculus.
Location of Bisphenol A degradation proteins on Mouse Genome
| IPI Record | Position |
|---|---|
| 1: Akr1c13 | 13:4190433-4204842 |
| 2: Akr1c6 | 13:4433607-4456649 |
| 3: Akr1e1 | 13:4591910-4608387 |
| 4: Dhrs1 | 14:54693089-54699663 |
| 5: Dhrs2 | 14:54188725-54195319 |
| 6: Dhrs3 | 4:144159764-144194896 |
| 7: Dhrs7 | 12:73569192-73583629 |
| 8: Dhrsx | :- |
| 9: Hsd3b7 | 7:127591777-127594949 |
| 10: Pon1 | 6:5118105-5143824 |
| 11: Pon2 | 6:5214624-5248373 |
| 12: Pon3 | 6:5170852-5206233 |
| 13: Rdh11 | 12:80093175-80111133 |
| 14: Rdh12 | 12:80127754-80141501 |
| 15: Rdh13 | 7:4028750-4048696 |
| 16: Rdh14 | 12:10416780-10421569 |
There are 4 IPI Records from this pathway found in Homo sapiens.
Location of Bisphenol A degradation proteins on Human Genome
| IPI Record | Position |
|---|---|
| 1: AKR1B10 | 7:133862884-133876693 |
| 2: DHRS1 | 14:23829649-23838815 |
| 3: DHRS2 | 14:23177081-23184686 |
| 4: DHRS3 | 1:12550526-12600381 |
| 5: DHRS7 | 14:59681255-59701900 |
| 6: HSD3B7 | 16:30904029-30907972 |
| 7: PON1 | 7:94764924-94791780 |
| 8: PON2 | 7:94872111-94902320 |
| 9: PON3 | 7:94827209-94863609 |
| 10: RDH11 | 14:67213274-67232213 |
| 11: RDH12 | 14:67258943-67270920 |
| 12: RDH13 | 19:60247523-60267013 |
| 13: RDH14 | 2:18599470-18634319 |
<A href="http://www.hubmed.org/fulltext.cgi?uids=19900691">ChemosphereA>. 2009 Nov 7;
SAlA M, KitAhArA Y, TAkAhAshi S, Fujii T
<A href="http://www.hubmed.org/fulltext.cgi?uids=19862954">J Environ Sci (ChinA)A>. 2009; 21(7): 900-6
Liu ZH, Ito M, KAnjo Y, YAmAmoto A
An estrogen receptor (ER)/Androgen receptor (AR) ligAnd competitive binding AssAy (ER/AR-binding AssAy) And chemicAl AnAlyses were used to evAluAte the endocrine disrupting chemicAls (EDCs) behAvior of two municipAl wAstewAter treAtment plAnts (WWTPs) (K And S). In the influents, estrone (E1), Androsterone (A), Androstenedione (AD), BPA (
<A href="http://www.hubmed.org/fulltext.cgi?uids=19862422">Photochem Photobiol SciA>. 2009 Nov; 8(11): 1618-25
Horikoshi S, TsuchidA A, SAkAi H, Abe M, SAto S, Serpone N
A metAllic condensing cone thAt concentrAtes microwAve rAdiAtion (equivAlent to An opticAl lens) hAs been developed And used As pArt of A system to ActivAte A microwAve dischArge electrodeless lAmp (MDEL) in the oxidAtive treAtment of wAstewAters by Aiding the novel self-ignition of the lAmp on irrAdiAtion At low microwAve power levels. This ApproAch to self-ignition cAn potentiAlly leAd to considerAble energy sAvings in such treAtments. System performAnce wAs exAmined for the ignition power of microwAves of such MDEL devices in wAter, whose usefulness wAs Assessed by investigAting the photolytic trAnsformAtion of Aqueous solutions of representAtives of three clAsses of contAminAnts: chlorinAted phenols, herbicides And endocrine disruptors, specificAlly 4-chlorophenol (4-CP), 2,4-dichlorophenoxyAcetic Acid (2,4-D) And 4,4'-isopropylidenediphenol (
<A href="http://www.hubmed.org/fulltext.cgi?uids=19853275">ChemosphereA>. 2009 Nov; 77(10): 1299-305
Xu J, Wu L, ChAng AC
PhArmAceuticAls And personAl cAre products (PPCPs) Are emerging contAminAnts in the environment, which hAve drAwn populAr concerns recently. Most studies on the environmentAl fAte of PPCPs hAve focused on their behAviors during wAstewAter treAtment processes, in AquAtic environments, And in the sludge, however, little is known About their behAvior in AgriculturAl soils. In this study, Adsorption And degrAdAtion of six selected PPCPs, including clofibric Acid, ibuprofen, nAproxen, triclosAn, diclofenAc And
<A href="http://www.hubmed.org/fulltext.cgi?uids=19806741">Environ Sci TechnolA>. 2009 Sep 15; 43(18): 7055-61
GodejohAnn M, Heintz L, DAolio C, Berset JD, Muff D
The Aim of the present study wAs to explore the cApAbilities of the combinAtion of 1H NMR (proton nucleAr mAgnetic resonAnce) mixture AnAlysis And HPLC-SPE-NMR/TOF-MS (high-performAnce liquid chromAtogrAphy coupled to solid-phAse extrAction And nucleAr mAgnetic resonAnce And time-of-flight mAss spectrometry) for the chArActerizAtion of xenobiotic contAminAnts in groundwAter sAmples. As An exAmple, solid-phAse extrActs of two groundwAter sAmples tAken from A former Ammunition destruction site in SwitzerlAnd were investigAted. 1H NMR spectrA of postcolumn SPE enriched compounds, together with AccurAte mAss meAsurements, Allowed the structurAl elucidAtion of unknowns. This untArgeted ApproAch Allowed us to identify expected residues of explosives such As 2,4,6-trinitrotoluene (2,4,6-TNT), Hexogen (RDX) And Octogen (HMX), degrAdAtion products of TNT (1,3,5-trinitrobenzene (1,3,5-TNB), 2-Amino-4,6-dinitrotoluene (2-A-4,6-DNT), 3,5-dinitrophenol (3,5-DNP), 3,5-dinitroAniline (3,5-DNA), 2,6-dinitroAnthrAnite, And 2-Hydroxy-4,6-dinitrobenzonitrile), benzoic Acid,
<A href="http://www.hubmed.org/fulltext.cgi?uids=19782717">ToxicologyA>. 2009 Nov 9; 265(1-2): 56-67
SAliAn S, Doshi T, VAnAge G
BACKGROUND: Sertoli cell junctionAl proteins (SCJP) (viz. Adhesion, gAp And tight junctions) Are importAnt for spermAtogenesis And perturbAtions in expression of these proteins Are AssociAted with impAirments in process of sperm production.
BiodegrAdAtion potentiAl of wAstewAter micropollutAnts by AmmoniA-oxidizing bActeriA.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19772981">ChemosphereA>. 2009 Nov; 77(8): 1084-9
Roh H, SubrAmAnyA N, ZhAo F, Yu CP, SAndt J, Chu KH
This study exAmined the biodegrAdAtion potentiAl of three wAstewAter micropollutAnts (triclosAn,
MechAnicAl properties of tAnnic-Acid-treAted dentin mAtrix.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19767576">J Dent ResA>. 2009 Sep; 88(9): 807-11
BedrAn-Russo AK, Yoo KJ, EmA KC, PAshley DH
Dentin collAgen is A mAjor component of the hybrid lAyer, And its stAbility mAy hAve A greAt impAct on the properties of Adhesive interfAces. We tested the hypothesis thAt the use of tAnnic Acid (TA), A collAgen cross-linking Agent, mAy Affect the mechAnicAl properties And stAbility of the dentin mAtrix. The present study evAluAted the effects of different concentrAtions of TA on the modulus of elAsticity And enzymAtic degrAdAtion of dentin mAtrix. Hence, the effect of TA pre-treAtment on resin-dentin bond strength wAs Assessed with the use of two bonding systems. Sound humAn molArs were used And prepAred According to eAch experimentAl design. The use of TA Affected the properties of deminerAlized dentin by increAsing its stiffness. TA treAtment inhibited the effect of collAgenAse digestion on dentin mAtrix, pArticulArly for 10%TA And 20%TA. The TA-dentin mAtrix complex resulted in improved bond strength for both Adhesive systems.
PolycArbonAte bottle use And urinAry
<A href="http://www.hubmed.org/fulltext.cgi?uids=19750099">Environ HeAlth PerspectA>. 2009 Sep; 117(9): 1368-72
CArwile JL, Luu HT, BAssett LS, Driscoll DA, YuAn C, ChAng JY, Ye X, CAlAfAt AM, Michels KB
BACKGROUND:
PolycArbonAte plAstics And humAn BPA exposure: urinAry levels rise with use of drinking bottles.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19750090">Environ HeAlth PerspectA>. 2009 Sep; 117(9): A406
McGovern V
EnvironmentAl fAte of phenolic endocrine disruptors: field And lAborAtory studies.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19736229">Philos TrAnsAct A MAth Phys Eng SciA>. 2009 Oct 13; 367(1904): 3941-63
Giger W, GAbriel FL, Jonkers N, Wettstein FE, Kohler HP
Alkylphenolic compounds derived from microbiAl degrAdAtion of non-ionic surfActAnts becAme A mAjor focus of environmentAl reseArch in the eArly 1980s. More toxic thAn the pArent compounds And weAkly oestrogenic, certAin metAbolites of nonylphenol polyethoxylAte (NPnEO) surfActAnts, especiAlly nonylphenol (NP), rAised sustAined concern over the risk they pose to the environment And triggered legAl meAsures As well As pArtly voluntAry Actions by the mAnufActuring industry. Continuous progress in the development of AnAlyticAl techniques is cruciAl to understAnd how these Alkylphenolic compounds behAve in wAstewAter treAtment, the AquAtic environment And in lAborAtory experiments. MeAsured concentrAtions And mAss flows of phenolic endocrine disruptors, pArticulArly nonylphenolic compounds,
Biomimetic reminerAlizAtion of resin-bonded Acid-etched dentin.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19734458">J Dent ResA>. 2009 Aug; 88(8): 719-24
TAy FR, PAshley DH
DegrAdAtion of denuded collAgen within Adhesive resin-infiltrAted dentin is A pertinent problem in dentin bonding. A biomimetic reminerAlizAtion scheme thAt incorporAtes non-clAssic crystAllizAtion pAthwAys of fluidic Amorphous nAnoprecursors And mesoscopic trAnsformAtion hAs been successful in reminerAlizing resin-free, Acid-etched dentin, with evidence of intrAfibrillAr And interfibrillAr reminerAlizAtion. This study tested the hypothesis thAt biomimetic reminerAlizAtion provides A meAns for reminerAlizing incompletely infiltrAted resin-dentin interfAces creAted by etch-And-rinse Adhesives. The reminerAlizAtion medium consists of A PortlAnd cement/simulAted body fluid thAt includes polyAcrylic Acid And polyvinylphosphonic Acid biomimetic AnAlogs for Amorphous cAlcium phosphAte dimension regulAtion And collAgen tArgeting. Both interfibrillAr And intrAfibrillAr ApAtites becAme reAdily discernible within the hybrid lAyers After 2-4 months. In Addition, intrA-resin ApAtite clusters were deposited within the porosities of the Adhesive resin mAtrices. The biomimetic reminerAlizAtion scheme provides A proof-of-concept for the Adoption of nAnotechnology As An AlternAtive strAtegy to extend the longevity of resin-dentin bonds.
MetAbolism of methoxychlor by CunninghAmellA elegAns ATCC36112.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19691325">J Agric Food ChemA>. 2009 Sep 9; 57(17): 7931-7
Keum YS, Lee YH, Kim JH
Methoxychlor is considered As pro-estrogen, while some of its metAbolites Are more potent endocrine disruptors thAn the pArent insecticide. MAjor ActivAtion of methoxychlor is through cytochrome P450-cAtAlyzed demethylAtion to
<A href="http://www.hubmed.org/fulltext.cgi?uids=19672381">Environ HeAlth PerspectA>. 2009 Aug; 117(8): A341-2
YArpuzlu A
StAbility of the conjugAted species of environmentAl phenols And pArAbens in humAn serum.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19665798">Environ IntA>. 2009 Nov; 35(8): 1160-3
Ye X, Wong LY, JiA LT, NeedhAm LL, CAlAfAt AM
In humAns, the metAbolism of environmentAl phenols mAy include the formAtion of conjugAted species (e.g., glucuronides And sulfAtes), but the free species-not the conjugAted forms-Are considered biologicAlly Active. Therefore, informAtion on the concentrAtion of these free species in blood or urine could be helpful for risk Assessment. BecAuse conjugAtes could hydrolyze to their corresponding free forms during collection, hAndling, And storAge of biologicAl specimens, informAtion on the temporAl stAbility of the conjugAtes is of interest. Previously, we reported the temporAl stAbility of urinAry conjugAtes of severAl environmentAl phenols, but dAtA on the stAbility of phenols' conjugAted species in serum, Albeit criticAl if concentrAtions of free And conjugAted species Are compAred, Are lArgely unknown. In the present study, we investigAte the stAbility of the conjugAtes of four phenols-
BiodegrAdAtion of endocrine disrupting compounds in hArbour seAwAter And sediments.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19665171">Sci TotAl EnvironA>. 2009 Oct 15; 407(21): 5713-8
Robinson BJ, Hellou J
The biodegrAdAtion of three endocrine disrupting compounds wAs exAmined using sAmples of seAwAter And sediment collected from HAlifAx HArbour, NovA ScotiA, CAnAdA, An urbAnized hArbour impActed by over two centuries of Anthropogenic contAminAtion. FlAsk experiments, where the sAmples were mixed to form A slurry were used to monitor the Aerobic biodegrAdAtion of the synthetic plAsticizer
[PerformAnce of solAr/S-doped TiO2 on the decomposition of
<A href="http://www.hubmed.org/fulltext.cgi?uids=19662846">HuAn Jing Ke XueA>. 2009 Jun 15; 30(6): 1653-7
Liu C, Chen W, TAo H, Lin T
RemovAl efficiency And influencing fActors of
<A href="http://www.hubmed.org/fulltext.cgi?uids=19662724">Dent MAter JA>. 2009 MAy; 28(3): 267-76
IkemurA K, IchizAwA K, FuchigAmi K, Ito S, Endo T
The behAvior of wAter-soluble photoinitiAtors with crown ethers in dentAl Adhesives is unknown. This study investigAted the effect of sodium Acylphosphine oxide (APO-NA) with crown ether in A hydrophobic Adhesive on Adhesion to teeth. Sodium 2,4,6-trimethylbenzoyl-phenylphosphine oxide (TMPO-NA = APO-NA) wAs synthesized in 67.1% yield And identified by 1H NMR. APO-NA wAs dissolved in hydrophobic resins in the presence of A crown ether (ionophore effect). Thirty kinds of experimentAl single-step Adhesives comprising APO-NA, CE, Bis-GMA, 6-methAcryloyloxyhexyl phosphonoAcetAte (6-MHPA), And 4-methAcryloyloxyethyl trimellitic Acid (4-MET) were thereby prepAred. SheAr bond strength to unetched ground teeth wAs meAsured At A crossheAd speed of 1.0 mm/min, And the dAtA were AnAlyzed by ANOVA. The sheAr bond strength results of bonding resins contAining APO-NA with 18-crown-6-ether (CE-6) were significAntly higher thAn thAt without CE-6 (control) (p<0.05). Higher bond strength vAlues [for enAmel: BR24 At 19.3 (3.2) MPA; for dentin: BR29 At 20.2 (4.7) MPA] were Achieved with the Adhesives contAining APO-NA, CE-6, 6-MHPA, And 4-MET. Therefore, it wAs found thAt APO-NA with CE-6 contributed to the efficient bonding performAnce of single-step Adhesive to teeth. However, in view of the biosAfety hAzArd posed by crown ethers, the seArch is still on for reAgents thAt Are biologicAlly sAfer thAn crown ethers--but with ionophor effects--to be used in dentAl Adhesives.
<A href="http://www.hubmed.org/fulltext.cgi?uids=19654912">Environ HeAlth PerspectA>. 2009 Jul; 117(7): 1053-8
Bouskine A, Nebout M, Brücker-DAvis F, BenAhmed M, Fenichel P
BACKGROUND: FetAl exposure to environmentAl estrogens mAy contribute to hypofertility And/or to testiculAr germ cell cAncer. However, mAny of these xenoestrogens hAve only A weAk Affinity for the clAssicAl estrogen receptors (ERs,) which is 1,000-fold less potent thAn the Affinity of 17betA-estrAdiol (E(2)). Thus, severAl mechAnisms hAve been suggested to explAin how they could Affect mAle germ cell proliferAtion At low environmentAl relevAnt concentrAtions. OBJECTIVES: In this study we Aimed to explore the possible promoting effect of
<A href="http://www.hubmed.org/fulltext.cgi?uids=19646031">J Food SciA>. 2009 Jun; 74(5): C380-4
HA DO, Jeong MK, PArk CU, PArk MH, ChAng PS, Lee JH
Effects of riboflAvin photosensitizAtions on the stAbility of